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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Popoola, Daniel O. Borrow, Amanda P. Sanders, Julia E. Nizhnikov, Michael E. Cameron, Nicole M. |
| Description | Country affiliation: United States Author Affiliation: Popoola DO ( Psychology Department, Center for Development and Behavioral Neuroscience, Binghamton University - SUNY, NY, USA.); Borrow AP ( Psychology Department, Center for Development and Behavioral Neuroscience, Binghamton University - SUNY, NY, USA.); Sanders JE ( Psychology Department, Center for Development and Behavioral Neuroscience, Binghamton University - SUNY, NY, USA.); Nizhnikov ME ( Psychology Department, Southern Connecticut State University, CT, USA.); Cameron NM ( Psychology Department, Center for Development and Behavioral Neuroscience, Binghamton University - SUNY, NY, USA. Electronic address: ncameron@binghamton.edu.) |
| Abstract | Gestational alcohol use is well documented as detrimental to both maternal and fetal health, producing an increase in offspring's tendency for alcoholism, as well as in behavioral and neuropsychological disorders. In both rodents and in humans, parental care can influence the development of offspring physiology and behavior. Animal studies that have investigated gestational alcohol use on parental care and/or their interaction mostly employ heavy alcohol use and single strains. This study aimed at investigating the effects of low gestational ethanol dose on parental behavior and its transgenerational transmission, with comparison between two rat strains. Pregnant Sprague Dawley (SD) and Long Evans (LE) progenitor dams (F0) received 1g/kg ethanol or water through gestational days 17-20 via gavage, or remained untreated in their home cages. At maturity, F1 female offspring were mated with males of the same strain and treatment and were left undisturbed through gestation. Maternal behavior was scored in both generations during the first six postnatal days. Arch-back nursing (ABN) was categorized as: 1, when the dam demonstrated minimal kyphosis; 2, when the dam demonstrated moderate kyphosis; and 3, when the dam displayed maximal kyphosis. Overall, SD showed greater amounts of ABN than LE dams and spent more time in contact with their pups. In the F0 generation, water and ethanol gavage increased ABN1 and contact with pups in SD, behaviors which decreased in treated LE. For ABN2, ethanol-treated SD dams showed more ABN2 than water-treated dams, with no effect of treatment on LE animals. In the F1 generation, prenatal exposure affected retrieval. Transgenerational transmission of LG was observed only in the untreated LE group. Strain-specific differences in maternal behavior were also observed. This study provides evidence that gestational gavage can influence maternal behavior in a strain-specific manner. Our results also suggest that the experimental procedure during gestation and genetic variations between strains may play an important role in the behavioral effects of prenatal manipulations. |
| File Format | HTM / HTML |
| ISSN | 00319384 |
| Volume Number | 148 |
| e-ISSN | 1873507X |
| Journal | Physiology & Behavior |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-09-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Prenatal Exposure Delayed Effects Species Specificity Toxicity Male Alcohol Drinking Journal Article Posture Discipline Physiology Time Factors Maternal Behavior Female Animals, Newborn Ethanol Rats, Long-evans Rats Rats, Sprague-dawley Chemically Induced Physiopathology Pregnancy Animals Grooming Nursing Central Nervous System Depressants Analysis Of Variance Discipline Behavioral Neuroscience |
| Content Type | Text |
| Resource Type | Article |
| Subject | Experimental and Cognitive Psychology Behavioral Neuroscience |
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