| Content Provider |
World Health Organization (WHO)-Global Index Medicus |
| Author |
Cabanillas, B. Vásquez-Ocmín, P. Zebiri, I. Rengifo, E. Sauvain, M. Le, H. L. Vaisberg, A. Voutquenne-Nazabadioko, L. Haddad, M. |
| Description |
Country affiliation: Peru Author Affiliation: Cabanillas B ( a Instituto de Investigaciones de la Amazonía Peruana (IIAP) , Iquitos , Peru.); Vásquez-Ocmín P ( b Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia , Lima , Peru.); Zebiri I ( c Institut de Chimie Moléculaire de Reims UMR CNRS, Université , de Reims BP 1039, 51687 , REIMS , Cedex , France.); Rengifo E ( a Instituto de Investigaciones de la Amazonía Peruana (IIAP) , Iquitos , Peru.); Sauvain M ( d Laboratoire de Pharmacochimie et Pharmacologie pour le Développement, Pharma-DEV, Université de Toulouse, UPS, UMR 152 , F-31062 Toulouse , Cedex 9 , France.); Le HL ( e Institut de Recherche pour le Développement (IRD) , UMR152, Mission IRD, Casilla 18-1209, Lima , Peru.); Vaisberg A ( d Laboratoire de Pharmacochimie et Pharmacologie pour le Développement, Pharma-DEV, Université de Toulouse, UPS, UMR 152 , F-31062 Toulouse , Cedex 9 , France.); Voutquenne-Nazabadioko L ( b Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia , Lima , Peru.); Haddad M ( c Institut de Chimie Moléculaire de Reims UMR CNRS, Université , de Reims BP 1039, 51687 , REIMS , Cedex , France.) |
| Abstract |
One new 5-alkylresorcinol glucoside (1) was isolated from leaves of Cybianthus magnus, along with 12 known compounds (2-13), isolated from four plants belonging to Myrsinaceae family. Their structures were determined on the basis of spectroscopic analysis and by comparison of their spectral data with those reported in the literature. Among the tested molecules, only compound 2 displayed a strong cytotoxic activity with IC50 values ranging between 22 and 100 µM for all cell lines tested. One new 5-alkylresorcinol glucoside (1) was isolated from leaves of Cybianthus magnus, along with 12 known compounds, isolated from four plants belonging to Myrsinaceae family (2, 3 isolated from C. magnus; 4-7, 10 and 11 isolated from Myrsine latifolia; 4, 8 and 9 isolated from Myrsine sessiflora; 6, 7, 10, 12 and 13 isolated from Myrsine congesta). Their structures were determined on the basis of spectroscopic analysis and by comparison of their spectral data with those reported in the literature. So far, only nine 5-alkylresorcinol glucosides were isolated from leaves of Grevillea robusta. Since resorcinols are known to exhibit strong cytotoxic activity, compounds 1 and 2 were tested against cell lines 3T3, H460, DU145 and MCF-7 for cytotoxicity in vitro and compounds 3-13 were tested for their antileishmanial activity. Compound 2 displayed a strong cytotoxic activity with IC50 values ranging between 22 and 100 µM for all tested cell lines. Compounds 3-13 were not active against Leishmania amazonensis amastigotes. |
| File Format |
HTM / HTML |
| ISSN |
14786419 |
| Issue Number |
3 |
| Volume Number |
30 |
| e-ISSN |
14786427 |
| Journal |
Natural Product Research |
| Language |
English |
| Publisher |
Taylor & Francis |
| Publisher Date |
2016-01-01 |
| Publisher Place |
Great Britain (UK) |
| Access Restriction |
One Nation One Subscription (ONOS) |
| Subject Keyword |
Research Support, Non-u.s. Gov't Discipline Natural products Antineoplastic Agents, Phytogenic Magnetic Resonance Spectroscopy Cell Survival Humans Plant Leaves Isolation & Purification Discipline Natural Products Pharmacology Drug Effects Journal Article Chemistry Animals Spectrometry, Mass, Electrospray Ionization Plant Roots Leishmania Cell Line, Tumor Myrsinaceae Resorcinols Glucosides Drug Screening Assays, Antitumor |
| Content Type |
Text |
| Resource Type |
Article |
| Subject |
Organic Chemistry Plant Science Analytical Chemistry Biochemistry |
