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A new sesquiterpene from the entomogenous fungus Phomopsis amygdali.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Ma, Xiaoli Wang, Wenshu Li, Erwei Gao, Fenghua Guo, Liangdong Pei, Yunfei
Description	Author Affiliation: Ma X ( a College of Life and Environmental Sciences, Minzu University of China , Beijing 100081 , P.R. China.); Wang W ( b State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences , Beijing 100101 , P.R. China.); Li E ( a College of Life and Environmental Sciences, Minzu University of China , Beijing 100081 , P.R. China.); Gao F ( c Beijing Engineering Research Center of Food Environment and Health, Minzu University of China , Beijing 100081 , P.R. China.); Guo L ( b State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences , Beijing 100101 , P.R. China.); Pei Y ( a College of Life and Environmental Sciences, Minzu University of China , Beijing 100081 , P.R. China.)
Abstract	A new sesquiterpene, (+)-S-1-methyl-abscisic-6-acid (1), together with five known compounds, (+)-S-abscisic acid (2), fusicoccin J (3), 3 -hydroxyfusicoccin J (4), (R)-5-hydroxymethylmellein (5) and 4-hydroxyphenethyl acetate (6) was isolated from the fermentation extract of Phomopsis amygdali, an entomogenous fungus isolated from Call midge. Their structures were determined mainly by analysis of MS and NMR spectroscopic data. Compounds 1-6 were tested for antimicrobial activity against three plant pathogenic fungi: Gibberella zeae, Verticillium albo-atrum, and Fusarium nivale, and two bacteria: Escherichia coli and Pseudomonas aeruginosa 2033E. As a result, compounds 1-4 displayed antibacterial activity against Gram-negative P. aeruginosa 2033E, and the minimum inhibition concentration (MIC value) of 1-4 is 30 µg/mL, 58 µg/mL, 26 µg/mL, and 26 µg/mL, respectively.
File Format	HTM / HTML
ISSN	14786419
Issue Number	3
Volume Number	30
e-ISSN	14786427
Journal	Natural Product Research
Language	English
Publisher	Taylor & Francis
Publisher Date	2016-01-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Ascomycota Chironomidae Research Support, Non-u.s. Gov't Discipline Natural products Microbiology Magnetic Resonance Spectroscopy Isolation & Purification Discipline Natural Products Pharmacology Fermentation Drug Effects Anti-bacterial Agents Journal Article Fungi Microbial Sensitivity Tests Chemistry Animals Sesquiterpenes Mass Spectrometry Bacteria Plant Diseases
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Plant Science Analytical Chemistry Biochemistry

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