NDLI: AXIN2 polymorphism and its association with prostate cancer in a Turkish population.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Pinarbasi, Ergun Gunes, Emine Gulsen Pinarbasi, Hatice Donmez, Gonca Silig, Yavuz
Spatial Coverage	Turkey
Description	Country affiliation: Turkey Author Affiliation: Pinarbasi E ( Faculty of Medicine, Department of Medical Biology, Cumhuriyet University, 58140, Sivas, Turkey. epinar@cumhuriyet.edu.tr)
Abstract	Polymorphism of AXIN2, a component of Wnt signaling, has been shown to play a role in tumorigenesis and dysregulated in cancer cells. In order to find out if AXIN2 polymorphism is a risk factor for prostate cancer, we analyzed eight polymorphic regions of this gene in 84 patients with prostate cancer and compared the results with 100 healthy controls in a Turkish population using PCR-RFLP methods. The genotype frequencies and risk factors of prostate cancer and control groups were analyzed by Chi-square test. We found a statistically significant result between prostate cancer risk and AXIN2 Intron2-956+16A/G (rs35285779) SNP. The frequency of the homozygous G/G (0%) and heterozygous A/G (18%) genotypes was significantly less in patients with prostate cancer than in healthy controls (7 and 32%, respectively) (P<0.05) for this SNP. When compared with the wild-type A/A genotype of the controls, prostate cancer patients with the A/G and G/G genotype showed reduced risk of cancer; the adjusted odds ratio (OR) for patients with the homozygous G/G genotype was 0.87 (95% CI: 0.81-0.95) and for heterozygous A/G genotype was 0.42 (95% CI: 0.20-0.85). We found no statistically significant association between controls and prostate cancer for other seven SNPs of AXIN2 including Exon1-148 C/T (rs2240308), Exon1-432 T/C (rs2240308), Exon5-1365 G/A (rs9915936), Exon5-1386 C/T (rs1133683), Intron5-1712+19 T/G, Exon7-2062 C/T, and Intron7-2141+73 G/A (rs4072245) (P>0.05). These results suggest that the AXIN2 Intron2 rs35285779 SNP is associated with development of prostate cancer as a protective SNP, while an association between other seven SNPs of the AXIN2 and risk of prostate cancer was not observed.
File Format	HTM / HTML
ISSN	13570560
Issue Number	4
Volume Number	28
e-ISSN	1559131X
Journal	Medical Oncology
Language	English
Publisher	Springer
Publisher Date	2011-12-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Research Support, Non-u.s. Gov't Humans Genotype Male Genetic Predisposition To Disease Journal Article Prostatic Neoplasms Turkey Polymorphism, Restriction Fragment Length Axin Protein Polymerase Chain Reaction Genetics Polymorphism, Single Nucleotide Aged Discipline Oncology
Content Type	Text
Resource Type	Article
Subject	Hematology Cancer Research Oncology

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