NDLI: Body mass index and waist circumference are predictor biomarkers of breast cancer risk in Iranian women.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Hajian-Tilaki, K. O. Gholizadehpasha, A. R. Bozorgzadeh, S. Hajian-Tilaki, E.
Spatial Coverage	Iran
Description	Country affiliation: Iran Author Affiliation: Hajian-Tilaki KO ( Department of Social Medicine and Health, Babol University of Medical Sciences, and Department of Surgery, Shahid Beheshti Hospital, Babol, Iran. drhajian@yahoo.com)
Abstract	Both obesity and breast cancer incidence increased dramatically during two recent decades in a rapidly changing society in northern Iran. In this study, we examined the ability of body mass index (BMI) and waist circumference (WC) as predictor biomarkers of breast cancer risk in Iranian women. In a case-control study of 100 new cases of histological confirmed breast cancer and 200 age-matched controls, in Babol, we measured weight, height, waist and hip circumference at time of diagnosis with standard methods. The data of demographic, characteristics, reproductive and lifestyle factors were collected by interview. We used both regression and receiver operator characteristics (ROC) analysis to estimate the predictive ability of BMI and WC for breast cancer as estimated by area under the curve (AUC). The results showed a significant difference in the mean of weight, BMI and WC between patients and controls in pre- and postmenopausal women (P<0.001). While after adjusting for BMI, no longer an association between WC and breast cancer was found. The overall accuracy of observed BMI and WC were 0.79 (95% CI: 0.74-0.84) and 0.68 (95% CI: 0.61-0.74), respectively. The accuracy of BMI and WC were 0.82 (95% CI: 0.76-0.89), 0.75(0.67-0.83) for premenopausal and 0.77(0.68-0.85), 0.60 (0.50-0.71) for postmenopausal women, respectively. BMI and WC are predictor biomarkers of breast cancer risk in both pre- and postmenopausal Iranian women while after adjusting for BMI, no longer an association between WC and breast cancer was observed. These findings imply to perform breast cancer screening program in women with a higher BMI and WC.
File Format	HTM / HTML
ISSN	13570560
Issue Number	4
Volume Number	28
e-ISSN	1559131X
Journal	Medical Oncology
Language	English
Publisher	Springer
Publisher Date	2011-12-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Body Mass Index Obesity Area Under Curve Complications Humans Middle Aged Risk Factors Breast Neoplasms Roc Curve Epidemiology Journal Article Case-control Studies Waist Circumference Iran Etiology Female Physiology Discipline Oncology
Content Type	Text
Resource Type	Article
Subject	Hematology Cancer Research Oncology

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