NDLI: Prognostic value of differential CCND1 expression in patients with resected gastric adenocarcinoma.

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Prognostic value of differential CCND1 expression in patients with resected gastric adenocarcinoma.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Ma, Liqiang Wang, Xiaoting Lan, Fenghua Yu, Yinghao Ouyang, Xuenong Liu, Wei Xie, Feilai Huang, Qiaojia
Description	Country affiliation: China Author Affiliation: Ma L ( Institute of Laboratory Medicine, Fuzhou General Hospital (Dongfang Hospital), 156 North Xi-er Huan Road, Fuzhou City, 350025, Fujian Province, China.)
Abstract	Cyclin D1 (CCND1) plays essential roles in cancer progression. In this study, CCND1 expression patterns in 211 cases of resected gastric adenocarcinoma (RGA) tissue were determined by immunohistochemistry, and the association between CCND1 expression levels and RGA prognosis was analyzed. RGA tissues displayed differential CCND1 expression (high expression, 52.1 %; n = 110, and low expression, 47.9 %; n = 101). CCND1 expression levels were related with median overall survival time (MST). MST in patients with high CCND1 expression was 43 months, whereas with low CCND1 expression it was 62 months (P = 0.013). When data were stratified by postoperative treatments and CCND1 expression levels, the MST for patients treated with fluoropyrimidine plus platinum (n = 140) was significantly longer than for those treated with fluoropyrimidine only (n = 71) in both high and low CCND1 expression groups (65.0 vs. 29.0 months, P = 0.041; and 74.5 vs. 33.0 months, P = 0.003, respectively). Cox multivariate analyses further confirmed that high CCND1 expression was related with poor prognosis in both treatment groups [hazard ratio (HR) 1.91, 95 % confidence interval (CI) 1.12-3.23; P = 0.017, and HR 2.14, 95 % CI 1.08-4.25; P = 0.029] and that fluoropyrimidine plus platinum was more effective than fluoropyrimidine only in high CCND1 (HR 0.47, 95 % CI 0.28-0.78; P = 0.004) and low CCND1 (HR 0.44; 95 % CI 0.23-0.82; P = 0.01) expression patients. Therefore, CCND1 may be used as a prognostic biomarker for patients with RGA.
File Format	HTM / HTML
ISSN	13570560
Issue Number	1
Volume Number	32
e-ISSN	1559131X
Journal	Medical Oncology
Language	English
Publisher	Springer
Publisher Date	2015-01-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Adenocarcinoma Immunohistochemistry Kaplan-meier Estimate Research Support, Non-u.s. Gov't Tumor Markers, Biological Prognosis Mortality Humans Middle Aged Proportional Hazards Models Male Biosynthesis Cyclin D1 Metabolism Journal Article Pathology Analysis Adult Female Aged Stomach Neoplasms Discipline Oncology
Content Type	Text
Resource Type	Article
Subject	Hematology Cancer Research Oncology

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