NDLI: Prodigiosin isolated from cell wall of Serratia marcescens alters expression of apoptosis-related genes and increases apoptosis in colorectal cancer cells.

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Prodigiosin isolated from cell wall of Serratia marcescens alters expression of apoptosis-related genes and increases apoptosis in colorectal cancer cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Hassankhani, Ramin Sam, Mohammad Reza Esmaeilou, Mohammad Ahangar, Prinaz
Description	Country affiliation: Iran Author Affiliation: Hassankhani R ( Department of Microbiology, Faculty of Science, Islamic Azad University, Urmia Branch, Urmia, Iran.)
Abstract	Colorectal cancer remains often refractory to classic therapies. In consequence, the search for new anti-tumor agents with minimal toxicity is of particular interest in colon cancer treatment. Prodigiosin as a secondary metabolite of Serratia marcescens induces apoptosis in various kinds of cancer cells with low toxicity on normal cells. In the present study, we evaluated the effect of prodigiosin on proliferation and expression of apoptotic-related genes in HT-29 cells. Malignant cells were treated to various concentrations of prodigiosin and proliferation rate, survivin, Bcl-2, Bax and Bad mRNA levels, caspase 3 activation and apoptosis were evaluated by different cellular and molecular techniques. Treatment of cells with increasing concentration of prodigiosin decreased significantly cell proliferation in a dose- and time-dependent manner. Following 48-h treatment, growth rate was measured to be 77 ± 6.8, 41.3 ± 3.1 and 46 ± 6.3 % for 100, 400 and 600 nM prodigiosin, respectively, compared to untreated cells. This molecule induced 61.7, 90 and 89 % decrease in survivin mRNA level as well as 1.9-, 2.8- and 2.2-fold increase in caspase 3 activation for indicated concentrations of prodigiosin, respectively. The level of Bcl-2 mRNA was inversely proportional to Bax and Bad mRNA levels. Low mRNA levels of Bcl-2 combined with high levels of Bax and Bad mRNAs were correlated to higher apoptosis rate in treated cells. Our data suggest that prodigiosin-induced apoptosis may ascribe to Bcl-2 and survivin inhibition in HT-29 cells and these genes may provide promising molecular targets of prodigiosin. Collectively, prodigiosin may have a great potential for colorectal cancer-directed therapy.
File Format	HTM / HTML
ISSN	13570560
Issue Number	1
Volume Number	32
e-ISSN	1559131X
Journal	Medical Oncology
Language	English
Publisher	Springer
Publisher Date	2015-01-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Adenocarcinoma Serratia Marcescens Research Support, Non-u.s. Gov't Cell Proliferation Cell Survival Prodigiosin Ht29 Cells Humans Antineoplastic Agents Pharmacology Drug Effects Anti-bacterial Agents Journal Article Pathology Apoptosis Regulatory Proteins Flow Cytometry Polymerase Chain Reaction Colorectal Neoplasms Discipline Oncology Apoptosis
Content Type	Text
Resource Type	Article
Subject	Hematology Cancer Research Oncology

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