NDLI: Correlation and malignant transformation of MSCs with the overexpression of SIL-R/GP130 under the tumor microenvironment.

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Correlation and malignant transformation of MSCs with the overexpression of SIL-R/GP130 under the tumor microenvironment.

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Correlation and malignant transformation of MSCs with the overexpression of SIL-R/GP130 under the tumor microenvironment.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Hou, Zhenyu Cui, Naiqiang Cui, Yunfeng Xing, Huizhi Liu, Wei
Description	Country affiliation: China Author Affiliation: Hou Z ( Nankai Hospital, Nankai Clinical School, Tianjin Medical University, Tianjin, China.)
Abstract	Mesenchymal stem cells (MSCs) can differentiate into chondrogenesis, osteogenesis, myocardium and nerve in specific conditions, but it may undergo malignant transformation when cultivated with tumor cells. This research was to provide preliminary experimental basis for the safe application of MSCs and seek for drugs to avoid the malignant transformation of MSCs in the treatment of tumor. Accordingly, four groups including experimental group, positive control group, negative contrast group and blank group were set. Experimental group was the co-culture group of MSCs and C6 glioma cells. Positive control group was the regular culture group of C6 glioma cells. Negative control group was the co-culture group of MSCs and astrocyte. And blank group was the regular culture group of MSCs. The results showed the expression of IL-6, and IL-6R significantly increased in the group of co-culture with C6; the proliferation situation of MSCs was obviously strengthened; MSCs performed a high expression of GP130, STAT-3, CyclinD1 and BCL-xl, which had statistical significance compared with the contrast group. It can be concluded that the malignant expression of MSCs was related to the overexpression and activation of SIL-R/GP130; and the excessive expression and activation of SIL-6R and GP130 might be one of the important reasons for malignant transformation of MSCs under the microenvironment.
File Format	HTM / HTML
ISSN	13570560
Issue Number	1
Volume Number	32
e-ISSN	1559131X
Journal	Medical Oncology
Language	English
Publisher	Springer
Publisher Date	2015-01-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Intracellular Signaling Peptides And Proteins Rats, Wistar Coculture Techniques Cytokine Receptor Gp130 Tumor Microenvironment Rats Metabolism Journal Article Pathology Animals Glioma Mesenchymal Stromal Cells Cell Transformation, Neoplastic Cell Line, Tumor Physiology Discipline Oncology
Content Type	Text
Resource Type	Article
Subject	Hematology Cancer Research Oncology

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