NDLI: HindIII polymorphism in the lipoprotein lipase gene and hypertensive intracerebral hemorrhage in the Chinese Han population.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Gu, Bin Zhao, Ying-Chun Yang, Zhi-Wen Li, Hong-Tao Yu, Fang-Ping
Spatial Coverage	China
Description	Country affiliation: China Author Affiliation: Gu B ( Department of Neurology, The Affiliated Shanghai Songjiang Central Hospital, Nanjing Medical University, Shanghai, China.); Zhao YC ( Department of Neurology, The Affiliated Shanghai Songjiang Central Hospital, Nanjing Medical University, Shanghai, China. Electronic address: zhaoyingchun9077@163.com.); Yang ZW ( Department of Neurology, The Affiliated Shanghai Songjiang Central Hospital, Nanjing Medical University, Shanghai, China.); Li HT ( Department of Neurology, The Affiliated Shanghai Songjiang Central Hospital, Nanjing Medical University, Shanghai, China.); Yu FP ( Department of Neurology, The Affiliated Shanghai Songjiang Central Hospital, Nanjing Medical University, Shanghai, China.)
Abstract	BACKGROUND: To investigate the relationship between the HindIII polymorphism and hypertensive intracerebral hemorrhage (HIH) and lipid metabolism. METHODS: A polymerase chain reaction-restriction fragment length polymorphism assay and the chain termination DNA sequencing method were used to determine the HindIII genotypes of 267 subjects, which included 120 cerebral hemorrhagic patients and 147 controls. The fasting levels of lipids and glucose in the plasma were used to measure the effect of genotype on HIH risk factors. RESULTS: The frequency of the T allele of the HindIII polymorphism in the HIH group was 90.8%. The frequency of the G allele was 9.2%. In the control group, the frequencies were 82.3% T and 17.7% G, which indicated that the proportion of the G allele in the HIH patient group was significantly lower than in the control group (P<.05). The frequency of GG+GT genotypes in HIH patients (P<.05) and the plasma triglyceride (TG) levels in these patients (P<.05) were also lower than in the control group. The levels of plasma TG, low-density lipoprotein cholesterol, glucose, systolic blood pressure, and diastolic blood pressure in the HIH group were higher than in the controls (P<.05). After controlling for risk factors related to HIH, the HindIII G allele was negatively correlated with the incidence of HIH (odds ratio=.417, 95% confidence interval: .193-.901). CONCLUSIONS: The HindIII G allele may be a protective factor against the development of HIH among the Han Chinese population.
File Format	HTM / HTML
ISSN	10523057
Issue Number	6
Volume Number	23
e-ISSN	15328511
Journal	Journal of Stroke and Cerebrovascular Diseases
Language	English
Publisher	Elsevier
Publisher Date	2014-07-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Lipoprotein Lipase Research Support, Non-u.s. Gov't Apolipoproteins B Humans Middle Aged Lipids Male Blood Journal Article Cholesterol, Hdl Discipline Cardiology China Apolipoprotein A-i Genetics Female Intracranial Hemorrhage, Hypertensive Genetic Association Studies Gene Frequency Blood Glucose Genotype Genetic Predisposition To Disease Aged, 80 And Over Asian Continental Ancestry Group Alleles Polymorphism, Single Nucleotide Aged
Content Type	Text
Resource Type	Article
Subject	Rehabilitation Neurology (clinical) Surgery Cardiology and Cardiovascular Medicine

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Replication of genetic associations with plasma lipoprotein traits in a multiethnic sample.

Apolipoprotein E gene polymorphism in psoriasis: a meta-analysis.

Association study of apolipoprotein L-I Lys166Glu and Ile244Met gene variants with obesity in Chinese subjects.

Genetic loci associated with plasma concentration of low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, apolipoprotein A1, and Apolipoprotein B among 6382 white women in genome-wide analysis with replication.

Physical activity modifies the effect of LPL, LIPC, and CETP polymorphisms on HDL-C levels and the risk of myocardial infarction in women of European ancestry.

Association between the LXR polymorphism and stroke in a Chinese population.

The HindIII polymorphism in the lipoprotein lipase gene predicts type 2 diabetes risk among Chinese adults.

Variants -250G/A and -514C/T in the LIPC gene are associated with hypertensive disorders of pregnancy in Chinese women.

A lipoprotein lipase gene polymorphism interacts with consumption of alcohol and unsaturated fat to modulate serum HDL-cholesterol concentrations.

HindIII polymorphism in the lipoprotein lipase gene and hypertensive intracerebral hemorrhage in the Chinese Han population.

Similar Documents

Replication of genetic associations with plasma lipoprotein traits in a multiethnic sample.

Apolipoprotein E gene polymorphism in psoriasis: a meta-analysis.

Association study of apolipoprotein L-I Lys166Glu and Ile244Met gene variants with obesity in Chinese subjects.

Genetic loci associated with plasma concentration of low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, apolipoprotein A1, and Apolipoprotein B among 6382 white women in genome-wide analysis with replication.

Physical activity modifies the effect of LPL, LIPC, and CETP polymorphisms on HDL-C levels and the risk of myocardial infarction in women of European ancestry.

Association between the LXR polymorphism and stroke in a Chinese population.

The HindIII polymorphism in the lipoprotein lipase gene predicts type 2 diabetes risk among Chinese adults.

Variants -250G/A and -514C/T in the LIPC gene are associated with hypertensive disorders of pregnancy in Chinese women.

A lipoprotein lipase gene polymorphism interacts with consumption of alcohol and unsaturated fat to modulate serum HDL-cholesterol concentrations.

HindIII polymorphism in the lipoprotein lipase gene and hypertensive intracerebral hemorrhage in the Chinese Han population.