NDLI: Synthesis and characterization of thermoresponsive copolymers for drug delivery.

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Synthesis and characterization of thermoresponsive copolymers for drug delivery.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Aerry, Swati De, Arnab Kumar, Ajeet Saxena, Amit Majumdar, D. K. Mozumdar, Subho
Description	Country affiliation: India Author Affiliation: Aerry S ( Department of Chemistry, University of Delhi, Delhi 110007, India.)
Abstract	We report the synthesis and characterization of two nontoxic, thermogelling drug delivery systems which are liquid at room temperatures but become a gel at physiological temperature (37°C) potentially leading to release of a drug molecule. We selected temperature as the stimulus for drug release as it is physiologically invariant. A free radical polymerization of N-isopropylacrylamide (NIPAM) and N-vinylpyrrolidone (VP) was carried out under nitrogen atmosphere in double-distilled water at two different temperatures (30°C and 70°C), and the copolymers obtained were characterized by various analytical techniques. The molar ratios of the two monomers were altered with increasing NIPAM content and their cloud point temperature or least critical solution temperature (LCST) was determined. The copolymer at 9:1 ratio of NIPAM to VP resulted in the formation of nanoparticle-based gel (NG1) at 30°C; however, at 70°C, a microgel (MG1) was formed. The LCST of the nanogel and microgel was 33.5-34°C and 36.5-37°C, respectively. Thus, both the copolymers are water soluble at room temperature, but distinct phases appear at physiological temperatures. We hypothesized that these copolymers on entrapment with a drug could be used for topical application to the skin or eye for controlled drug delivery applications. Toxicological studies revealed that the copolymers are nontoxic in HeLa cells. Finally, our experiments show that a model drug [bovine serum albumin (BSA)] is released at 37°C with zero-order kinetics and confirmed using multiple well-known mathematical models.
File Format	HTM / HTML
ISSN	15493296
Issue Number	7
Volume Number	101
e-ISSN	15524965
Journal	Journal of Biomedical Materials Research Part A
Language	English
Publisher	Wiley
Publisher Date	2013-07-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Temperature Cross-linking Reagents Humans Delayed-action Preparations Spectroscopy, Fourier Transform Infrared Journal Article Drug Delivery Systems Light Micelles Acrylic Resins Scattering, Radiation Polymers Microscopy, Electron, Transmission Microscopy, Electron, Scanning Magnetic Resonance Spectroscopy Chemical Synthesis Hot Temperature Discipline Biomedical Engineering Particle Size Chemistry Pyrrolidinones Serum Albumin, Bovine Calorimetry, Differential Scanning Kinetics Hela Cells
Content Type	Text
Resource Type	Article
Subject	Ceramics and Composites Metals and Alloys Biomaterials Biomedical Engineering

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