NDLI: Development of a bone reconstruction technique using a solid free-form fabrication (SFF)-based drug releasing scaffold and adipose-derived stem cells.

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Development of a bone reconstruction technique using a solid free-form fabrication (SFF)-based drug releasing scaffold and adipose-derived stem cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Lee, Jin Woo Kim, Ki-Joo Kang, Kyung Shin Chen, Shaochen Rhie, Jong-Won Cho, Dong-Woo
Description	Country affiliation: United States Author Affiliation: Lee JW ( Department of NanoEngineering, The University of California, San Diego, La Jolla, California 92093-0448, USA.)
Abstract	For tissue regeneration, three essential components of scaffolds, signals (biomolecules), and cells are required. Moreover, because bony defects are three-dimensional in many clinical circumstances, an exact 3D scaffold is important. Therefore, we proposed an effective reconstruction tool for cranial defects using human adipose-derived stem cells (hADSCs) and a 3D functional scaffold fabricated by solid free-form fabrication (SFF) technology that secretes biomolecules. We fabricated poly(propylene fumarate)-based 3D scaffolds with embedded microsphere-deliverable bone morphogenetic protein-2 (BMP-2) by microstereolithography. BMP-2-loaded SFF scaffolds with/without hADSCs (SFF/BMP/hADSCs scaffolds and SFF/BMP scaffolds, respectively) and BMP-2-unloaded SFF scaffolds (SFF scaffolds) were then implanted in rat crania, and in vivo bone formation was observed. Analyses of bone formation areas using micro-computed tomography (micro-CT) showed the superiority of SFF/BMP/hADSCs scaffolds. Hematoxylin and eosin stain, Masson's trichrome stain, and collagen type-I stain supported the results of the micro-CT scan. And human leukocyte antigen-ABC showed that seeded, differentiated hADSCs were well grown and changed to the bone tissue at the inside of the scaffold. Results showed that our combination of a functional 3D scaffold and hADSCs may be a useful tool for improving the reconstruction quality of severe bony defects in which thick bone is required.
File Format	HTM / HTML
ISSN	15493296
Issue Number	7
Volume Number	101
e-ISSN	15524965
Journal	Journal of Biomedical Materials Research Part A
Language	English
Publisher	Wiley
Publisher Date	2013-07-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Immunohistochemistry Cell Proliferation Coloring Agents Humans Cytology Adipocytes Journal Article Drug Delivery Systems Stem Cells Tissue Scaffolds Paraffin Embedding Microspheres Subcutaneous Fat Physiology Tissue Fixation Tissue Engineering Bone Density Bone Morphogenetic Protein 2 Cell Separation Abnormalities Pharmacology Bone Development Drug Effects Therapeutic Use Absorbable Implants Discipline Biomedical Engineering Growth & Development Biocompatible Materials Skull
Content Type	Text
Resource Type	Article
Subject	Ceramics and Composites Metals and Alloys Biomaterials Biomedical Engineering

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