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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Sobol, Marcin Bartkowiak, Artur de Haan, Bart de Vos, Paul |
| Description | Country affiliation: Poland Author Affiliation: Sobol M ( Center of Bioimmobilisation and Innovative Packaging Materials, West Pomeranian University of Technology, Szczecin 71270, Poland. marcin.sobol@zut.edu.pl) |
| Abstract | The majority of cell encapsulation systems applied so far are based on polyelectrolyte complexes of alginate and polyvalent metal cations. Although widely used, these systems suffer from the risk of disintegration. This can be partially solved by applying chitosan as additional outer membrane. However, chitosan can be dissolved in water only at a low pH, which limits its use in the field of bioencapsulation. In this study, novel primary and tertiary amine chitosan derivatives have been synthesized, which may be dissolved at pH 7.0, and retain the ability to effectively form additional membrane on the surface of alginate beads. As aqueous solutions tertiary amines dimethylamino-1-propyl-chitosan and dimethylethylamine-chitosan with linear hydrochloride aliphatic chains had the lowest toxicity, whereas dimethylpropylamine-chitosan, diethylaminoethyl-chitosan, and diisopropylaminoethyl-chitosan with branched hydrochloride aliphatic were cytotoxic to the majority of tested cells. When applied as polyelectrolyte complexation agent on the surface of alginate beads, none of the derivates had any negative effect on the metabolic activity of encapsulated beta-cells. |
| File Format | HTM / HTML |
| ISSN | 15493296 |
| Issue Number | 7 |
| Volume Number | 101 |
| e-ISSN | 15524965 |
| Journal | Journal of Biomedical Materials Research Part A |
| Language | English |
| Publisher | Wiley |
| Publisher Date | 2013-07-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Water Cell Line Cell Proliferation Magnetic Resonance Spectroscopy Toxicity Cell Survival Cells, Cultured Chitin Alginates Oligosaccharides Indicators And Reagents Nitrogen Spectroscopy, Fourier Transform Infrared Drug Effects Journal Article Discipline Biomedical Engineering Chemistry Animals Capsules Drug Compounding Chitosan Hydrogen-ion Concentration Analogs & Derivatives Methods |
| Content Type | Text |
| Resource Type | Article |
| Subject | Ceramics and Composites Metals and Alloys Biomaterials Biomedical Engineering |
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