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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Power, John D. O'Brien, John Talbot, Brian Barry, Michael Kavanagh, Pierce |
| Description | Author Affiliation: Power JD ( Forensic Science Laboratory, Garda HQ, Dublin 8, Ireland); O'Brien J ( School of Chemistry, Trinity College, Dublin 2, Ireland.); Talbot B ( School of Pharmacy and Pharmaceutical Sciences, Trinity College, Dublin 2, Ireland.); Barry M ( Department of Pharmacology and Therapeutics, School of Medicine, Trinity Centre for Health Sciences, St. James Hospital, Dublin 8, Ireland.); Kavanagh P ( Department of Pharmacology and Therapeutics, School of Medicine, Trinity Centre for Health Sciences, St. James Hospital, Dublin 8, Ireland.) |
| Abstract | During the analysis of a Customs' importation case for the suspected presence of controlled drugs, amphetamine was found to be present. The samples were also found to contain by-products from the amphetamine synthesis and these included benzyl cyanide, phenylacetone (P2P), methyl-phenyl-pyrimidines, N-formylamphetamine, a pair of naphthalene derivatives and amphetamine dimers. During the experimental investigation of the naphthalenes formation, a series of syntheses involved the acid hydrolysis of -phenylacetoacetonitrile (APAAN). In one such experiment with sulfuric acid, a white substance was visibly deposited on the glassware and this was identified as the pyridone derivative, 4,6-dimethyl-3,5-diphenylpyridin-2-one. This compound was subsequently found to be present in the amphetamine product seized by the Customs and also in the final product of our own laboratory synthesized amphetamine (APAAN hydrolyzed to P2P/Leuckart reaction). Interestingly, the, 4,6-dimethyl-3,5-diphenylpyridin-2-one was not found when commercially supplied P2P underwent the Leuckart reaction to yield amphetamine. This suggests that 4,6-dimethyl-3,5-diphenylpyridin-2-one may be a route specific marker to the use of APAAN as a starting material in the synthesis of P2P and subsequent Leuckart reaction to yield amphetamine. |
| File Format | HTM / HTML |
| ISSN | 03790738 |
| Journal | Forensic Science International |
| Volume Number | 241 |
| e-ISSN | 18726283 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2014-08-01 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Forensic Science |
| Content Type | Text |
| Resource Type | Article |
| Subject | Law Pathology and Forensic Medicine |
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