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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Häkkinen, Margareeta Vuori, Erkki Kalso, Eija Gergov, Merja Ojanperä, Ilkka |
| Spatial Coverage | Finland |
| Description | Author Affiliation: Häkkinen M ( Hjelt Institute, Department of Forensic Medicine, University of Helsinki, Kytösuontie 11, P.O. Box 40, Helsinki FI-00014, Finland. Electronic address: margareeta.hakkinen@helsinki.fi.); Vuori E ( Hjelt Institute, Department of Forensic Medicine, University of Helsinki, Kytösuontie 11, P.O. Box 40, Helsinki FI-00014, Finland.); Kalso E ( Institute of Clinical Medicine, University of Helsinki and Pain Clinic, Helsinki University Central Hospital, Helsinki, Finland.); Gergov M ( Hjelt Institute, Department of Forensic Medicine, University of Helsinki, Kytösuontie 11, P.O. Box 40, Helsinki FI-00014, Finland.); Ojanperä I ( Hjelt Institute, Department of Forensic Medicine, University of Helsinki, Kytösuontie 11, P.O. Box 40, Helsinki FI-00014, Finland.) |
| Abstract | Pregabalin (PRG) and gabapentin (GBP) are used in the treatment of neuropathic pain and epilepsy, and PRG also in generalized anxiety disorder. There is increasing evidence that PRG possesses considerable abuse potential. PRG may have a higher addiction potential than GBP due to its rapid absorption and faster onset of action. Our objective is to estimate the proportion of all PRG- and GBP-related fatalities attributable to PRG and GBP abuse. We investigated all medico-legal death cases in Finland in which PRG or GBP was found in postmortem toxicology during 2010-2011. PRG was found in 316 cases and GBP in 43 cases. Drug abuse was associated with 48.1% of the PRG and 18.6% of the GBP findings. PRG poisoning accounted for 10.1% of all PRG cases and GBP poisoning for 4.7% of all GBP cases. In the drug abuser cases, PRG poisoning represented 19.1%, and GBP poisoning 12.5%. The median blood concentration of PRG was 15 mg/L in the abuser group and 5.8 mg/L in the other cases. For GBP, these concentrations were 12 mg/L and 8.3mg/L, respectively. In the PRG abuser group, 91.4% of cases showed concomitant opioid use, while in the rest of these cases neither alcohol nor opioids were detected, but other central nervous system acting drugs were found in each abuser case. In the GBP abuser group, 87.5% of cases showed concomitant opioid use. PRG abuse with high doses is increasingly common and can be fatal when combined with opioids. |
| File Format | HTM / HTML |
| ISSN | 03790738 |
| Volume Number | 241 |
| e-ISSN | 18726283 |
| Journal | Forensic Science International |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2014-08-01 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Research Support, Non-u.s. Gov't Amines Humans Middle Aged Male Forensic Toxicology Pregabalin Epidemiology Blood Journal Article Limit Of Detection Young Adult Substance-related Disorders Mass Spectrometry Chromatography, Liquid Adult Female Discipline Forensic Science Adverse Effects Narcotics Mortality Gamma-aminobutyric Acid Aged, 80 And Over Anticonvulsants Adolescent Finland Cyclohexanecarboxylic Acids Aged Poisoning Postmortem Changes Analogs & Derivatives |
| Content Type | Text |
| Resource Type | Article |
| Subject | Law Pathology and Forensic Medicine |
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