NDLI: Endocrine disruption due to estrogens derived from humans predicted to be low in the majority of U.S. surface waters.

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Endocrine disruption due to estrogens derived from humans predicted to be low in the majority of U.S. surface waters.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Anderson, Paul D. Johnson, Andrew C. Pfeiffer, Danielle Caldwell, Daniel J. Hannah, Robert Mastrocco, Frank Sumpter, John P. Williams, Richard J.
Spatial Coverage	United States
Description	Country affiliation: United States Author Affiliation: Anderson PD ( ARCADIS U.S., Chelmsford, Massachusetts, USA. paul.anderson@arcadis-us.com)
Abstract	In an effort to assess the combined risk estrone (E1), 17ß-estradiol (E2), 17 -ethinyl estradiol (EE2), and estriol (E3) pose to aquatic wildlife across United States watersheds, two sets of predicted-no-effect concentrations (PNECs) for significant reproductive effects in fish were compared to predicted environmental concentrations (PECs). One set of PNECs was developed for evaluation of effects following long-term exposures. A second set was derived for short-term exposures. Both sets of PNECs are expressed as a 17ß-estradiol equivalent (E2-eq), with 2 and 5 ng/L being considered the most likely levels above which fish reproduction may be harmed following long-term and short-term exposures, respectively. A geographic information system-based water quality model, Pharmaceutical Assessment and Transport Evaluation (PhATE™), was used to compare these PNECs to mean and low flow concentrations of the steroid estrogens across 12 U.S. watersheds. These watersheds represent approximately 19% of the surface area of the 48 North American states, contain 40 million people, and include over 44,000 kilometers of rivers. This analysis determined that only 0.8% of the segments (less than 1.1% of kilometers) of these watersheds would have a mean flow E2-eq concentration exceeding the long-term PNEC of 2.0 ng/L; only 0.5% of the segments (less than 0.8% of kilometers) would have a critical low flow E2-eq exceeding the short-term PNEC of 5 ng/L. Those few river segments where the PNECs were exceeded were effluent dominated, being either headwater streams with a publicly owned treatment works (POTW), or flowing through a highly urbanized environment with one or several POTWs. These results suggest that aquatic species in most U.S. surface waters are not at risk from steroid estrogens that may be present as a result of human releases.
File Format	HTM / HTML
ISSN	07307268
Issue Number	6
Volume Number	31
e-ISSN	15528618
Journal	Environmental Toxicology and Chemistry
Language	English
Publisher	Wiley
Publisher Date	2012-06-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Water Pollution, Chemical Water Pollutants, Chemical Research Support, Non-u.s. Gov't Toxicity United States Discipline Environmental Health Estrogens Humans Discipline Toxicology Estradiol Endocrine Disruptors Journal Article Fishes Discipline Chemistry Estriol Risk Assessment Rivers Ethinyl Estradiol Chemistry Animals Analysis Urbanization Estrone Statistics & Numerical Data Water Supply
Content Type	Text
Resource Type	Article
Subject	Environmental Chemistry Health, Toxicology and Mutagenesis

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Comparing predicted estrogen concentrations with measurements in US waters.

Behaviour of estrogenic endocrine-disrupting chemicals in permeable carbonate sands

Predicted-no-effect concentrations for the steroid estrogens estrone, 17ß-estradiol, estriol, and 17 -ethinylestradiol.

Estrogenic effects along the river Saale.

Impact of climate change and population growth on a risk assessment for endocrine disruption in fish due to steroid estrogens in England and Wales.

Estrogen pollution in a highly productive ecosystem off central-south Chile.

Occurrence and distribution of endocrine-disrupting compounds in the Honghu Lake and East Dongting Lake along the Central Yangtze River, China.

Photodegradation of estrogenic endocrine disrupting steroidal hormones in aqueous systems: Progress and future challenges.

Processes for the elimination of estrogenic steroid hormones from water: a review.

Endocrine disruption due to estrogens derived from humans predicted to be low in the majority of U.S. surface waters.

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Endocrine disruption due to estrogens derived from humans predicted to be low in the majority of U.S. surface waters.