NDLI: The effect of sleep apnea syndrome on the development of diabetic nephropathy in patients with type 2 diabetes.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Buyukaydin, Banu Akkoyunlu, Muhammed Emin Kazancioglu, Rumeyza Karakose, Fatma Ozcelik, Hatice Kutbay Erkoc, Reha Kart, Levent
Spatial Coverage	Turkey
Description	Country affiliation: Turkey Author Affiliation: Buyukaydin B ( Bezmialem Vakif University Faculty of Medicine, Department of Internal Medicine, Istanbul, Turkey. bbuyukaydin@hotmail.com)
Abstract	AIMS: Type 2 diabetes mellitus and obstructive sleep apnea syndrome (OSAS) are serious comorbidities. Effects of OSAS on diabetic microvascular complications are ongoing research subjects. We evaluated the incidence of OSAS in Type 2 diabetes mellitus patients with nephropathy and with no renal involvement. METHODS: A total of 52 people with diabetes were enrolled in this study. Patients body mass indices were calculated and fasting glucose, glycosylated hemoglobin, urea, creatinine, total lipid profile, and urinary albumin excretion were evaluated. Full polysomnography was used to detect sleep disorders. RESULTS: Baseline characteristics and laboratory results of the patients were similar. Meeting criteria for OSAS was detected in 35 of the 54 patients (67.3%). 25 patients (48%) had mild, six patients (11.5%) had moderate, and four patients (7.7%) had severe sleep disorders. There was no significant relationship between respiratory obstructive parameters and microalbuminuria (R=0.91, p=0.362). Substantial correlation was detected between lower values of serum triglyceride levels and lower respiratory indices (R=0.299, p=0.031). CONCLUSIONS: In type 2 diabetes accompanying OSAS affects glucose regulation but its effect on nephropathy development is currently a subject of research.
File Format	HTM / HTML
ISSN	01688227
Issue Number	1
Volume Number	98
e-ISSN	18728227
Journal	Diabetes Research and Clinical Practice
Language	English
Publisher	Elsevier
Publisher Date	2012-10-01
Publisher Place	Ireland
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Prospective Studies Biological Markers Humans Middle Aged Lipids Male Albuminuria Epidemiology Blood Journal Article Female Diabetes Mellitus, Type 2 Body Mass Index Creatinine Diabetic Nephropathies Complications Hemoglobin A, Glycosylated Sleep Apnea, Obstructive Blood Glucose Polysomnography Metabolism Physiopathology Turkey Discipline Endocrinology C-peptide Multicenter Study
Content Type	Text
Resource Type	Article
Subject	Endocrinology, Diabetes and Metabolism Internal Medicine Endocrinology

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