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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kariz, Stojan Nikolajevic Starcevic, Jovana Petrovic, Daniel |
| Spatial Coverage | Slovenia |
| Description | Country affiliation: Slovenia Author Affiliation: Kariz S ( Internal Department, General Hospital Izola, Polje 35, 6310 Izola, Slovenia. stojan.kariz@siol.net) |
| Abstract | AIM: In the present study we investigated the association between genetic polymorphisms with functional effects on redox regulation: Val16Ala of manganese superoxide dismutase (MnSOD), polymorphic deletions of glutathione S-transferases M1 (GSTM1) and T1 (GSTT1) and Ile105Val of glutathione S-transferase P1 (GSTP1) and myocardial infarction (MI) in a group of patients with type 2 diabetes mellitus. METHODS: The study population consisted of 463 Caucasian subjects with type 2 diabetes mellitus of more than 10 years' duration: 206 patients with MI and 257 patients with no history of coronary artery disease (CAD). Genotypes were determined by polymerase chain reaction (PCR) with restriction fragment length polymorphism (RFLP) and with multiplex PCR. RESULTS: The genotype distributions of tested single nucleotide polymorphisms did not show significant difference between cases and controls. After adjustment for age, gender, smoking, BMI, duration of diabetes and lipid parameters carriers of GSTM1/GSTT1-null haplotype showed an increased risk for MI (OR=3.22, 95% CI 1.37-5.04, p=0.03). CONCLUSIONS: The GSTM1/GSTT1 haplotype might be a genetic risk factor for MI in patients with type 2 diabetes mellitus. |
| File Format | HTM / HTML |
| ISSN | 01688227 |
| Issue Number | 1 |
| Volume Number | 98 |
| e-ISSN | 18728227 |
| Journal | Diabetes Research and Clinical Practice |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2012-10-01 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Cross-sectional Studies Oxidative Stress Biological Markers Humans Middle Aged Lipids Male Epidemiology Blood Journal Article Polymerase Chain Reaction Genetics Female Diabetes Mellitus, Type 2 Glutathione Transferase Slovenia Alanine Risk Factors Blood Glucose European Continental Ancestry Group Genotype Logistic Models Metabolism Genetic Predisposition To Disease Myocardial Infarction Polymorphism, Restriction Fragment Length Discipline Endocrinology Valine Polymorphism, Single Nucleotide Diabetic Angiopathies Glutathione S-transferase Pi Superoxide Dismutase |
| Content Type | Text |
| Resource Type | Article |
| Subject | Endocrinology, Diabetes and Metabolism Internal Medicine Endocrinology |
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