NDLI: Type 2 diabetes and/or its treatment leads to less cognitive impairment in Alzheimer's disease patients.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Domínguez, Raúl O. Marschoff, Enrique R. González, Silvia E. Repetto, Marisa G. Serra, Jorge A.
Spatial Coverage	Argentina
Description	Country affiliation: Argentina Author Affiliation: Domínguez RO ( Sirio-Libanés Hospital, Department of Neurology, School of Medicine, University of Buenos Aires (UBA), Buenos Aires, Argentina.)
Abstract	AIM: To evaluate the cognitive performance of a homogeneous population of Alzheimer's disease (AD), non-demented Type 2 Diabetes Mellitus (DIAB), demented with concomitant diseases (AD+DIAB) and healthy control subjects. AD is a progressive dementia disorder characterized clinically by impairment of memory, cognition and behavior. Recently, a major research interest in AD has been placed on early evaluation. Diabetes is one of the clinical conditions that represent the greatest risk of developing oxidative stress and dementia. Glucose overload, leading to the development of impaired-induced insulin secretion in DIAB and has been suggested to slow or deter AD pathogenesis. METHODS: The degree of cognitive impairment was determined on the Alzheimer Disease Assessment Scale-Cognitive (ADAS-Cog) and the Folstein's Mini Mental State Examination (MMSE); the severity of dementia was quantified applying the Clinical Dementia Rating (CDR) test; the Hamilton test was employed to evaluate depressive conditions; the final population studied was 101 subjects. RESULTS: The cognitive deterioration is statistically significantly lower (p<0.05) in AD+DIAB patients as compared with AD patients. CONCLUSIONS: In this longitudinal study the superimposed diabetic condition was associated with a lower rate of cognitive decline, while diabetic non-demented patients and controls present normal scores.
File Format	HTM / HTML
ISSN	01688227
Issue Number	1
Volume Number	98
e-ISSN	18728227
Journal	Diabetes Research and Clinical Practice
Language	English
Publisher	Elsevier
Publisher Date	2012-10-01
Publisher Place	Ireland
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Geriatric Assessment Research Support, Non-u.s. Gov't Comparative Study Oxidative Stress Humans Male Blood Journal Article Hypoglycemic Agents Psychiatric Status Rating Scales Female Diabetes Mellitus, Type 2 Severity Of Illness Index Argentina Drug Therapy Pharmacology Alzheimer Disease Metabolism Insulin Drug Effects Disease Progression Physiopathology Neuropsychological Tests Pilot Projects Discipline Endocrinology Cognition Disorders Aged Thiazolidinediones Longitudinal Studies Hippocampus
Content Type	Text
Resource Type	Article
Subject	Endocrinology, Diabetes and Metabolism Internal Medicine Endocrinology

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