NDLI: Altered immune profile from pre-diabetes to manifestation of type 1 diabetes.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Rydén, Anna Faresjö, Maria
Spatial Coverage	Sweden
Description	Country affiliation: Sweden Author Affiliation: Rydén A ( Division of Paediatrics & Diabetes Research Centre, Department of Clinical & Experimental Medicine, Faculty of Health Sciences, Linköping University, S-581 85 Linköping, Sweden.)
Abstract	BACKGROUND: While the mechanisms leading to ß-cell destruction and clinical onset of T1D are still unclear, the composition of the immune profile is probably important for the outcome of immune activity. The aim of this study was to investigate the composition and possible changes of the immunological profile, spontaneously and following stimulation with the autoantigens GAD65, and HSP60, at high-risk and T1D onset and further to 8 months post diagnosis. METHODS: Fifteen first-degree relatives of T1D patients with a high risk of developing the disease within five years, 25 children approximately four days and 8 months after diagnosis of T1D and 16 healthy children were included in the study. Cytokines (IL-1ß, -6, -7, -10, -13, -17, IFN-Î³ and TNF- ) and chemokines (CCL2, -3, -4, -5 and CXCL10) associated with Th1, Th2, Tr1 and inflammatory cells were detected in cell culture supernatants by Luminex-technique, and markers associated with regulatory T-cells (FOXP3, CTLA-4 and TGF-ß) by real-time RT-PCR. RESULTS: High-risk individuals differed in immunity from that seen in healthy and T1D children. High-risk individuals had a low TNF- response and fewer responders from mitogen exposure as well as low spontaneous secretions of IL-13 compared to healthy children. High-risk individuals that later developed T1D, had a lower FOXP3 and CTLA-4 mRNA expression, following stimulation with GAD65, in combination with higher secretion of the pro-inflammatory chemokine CCL4. CONCLUSION: Changes in immunity seen in individuals with high risk of developing T1D points to alterations/actions in the immune system already early in the pre-diabetic phase.
File Format	HTM / HTML
ISSN	01688227
Issue Number	1
Volume Number	100
e-ISSN	18728227
Journal	Diabetes Research and Clinical Practice
Language	English
Publisher	Elsevier
Publisher Date	2013-04-01
Publisher Place	Ireland
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Research Support, Non-u.s. Gov't Humans Child, Preschool Male Mitochondrial Proteins Epidemiology Journal Article Chaperonin 60 Sweden Immunology Diabetes Mellitus, Type 1 Prediabetic State Genetics Female Child Cytokines Real-time Polymerase Chain Reaction Glutamate Decarboxylase T-lymphocytes, Regulatory Metabolism Tumor Necrosis Factor-alpha Physiopathology Discipline Endocrinology Membrane Transport Proteins Adolescent Up-regulation Forkhead Transcription Factors Age Of Onset Chemokines
Content Type	Text
Resource Type	Article
Subject	Endocrinology, Diabetes and Metabolism Internal Medicine Endocrinology

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