NDLI: Similarities and differences in cardiometabolic risk factors among remote Aboriginal Australian and Canadian cohorts.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Maple-Brown, Louise J. Brimblecombe, Julie Connelly, Philip W. Harris, Stewart B. Mamakeesick, Mary Zinman, Bernard O'Dea, Kerin Hanley, Anthony J.
Spatial Coverage	Canada Australia
Description	Country affiliation: Australia Author Affiliation: Maple-Brown LJ ( Menzies School of Health Research, Charles Darwin University, Casuarina, Australia. louise.maple-brown@menzies.edu.au)
Abstract	AIM: Indigenous populations of Australia and Canada experience disproportionately high rates of chronic disease. We hypothesized that despite the common outcome of increased diabetes prevalence, differences in cardiometabolic risk profile may exist between these populations. METHODS: We compared community-based data on cardiometabolic risks in Aboriginal Australians (n=297 without, 45 with diabetes), and Aboriginal Canadians (n=409 without, 87 with diabetes). RESULTS: Despite strikingly lower weight (62 vs 83 kg, p<0.0001) and body mass index (BMI, 22 vs 29 kg/m(2), p<0.0001), Aboriginal Australians without diabetes had similar waist-hip ratio (WHR, 0.91 vs 0.91, p=0.732), lower HDL-cholesterol (0.97 vs 1.25 mmol/L, p<0.0001) and higher HbA1c (5.4 vs 5.2%, p<0.0001) than Aboriginal Canadians without diabetes. Waist was the obesity measure most strongly related to diabetes or cardiometabolic risk in Australians while BMI performed similarly to other obesity measures only in Canadians. Multiple regression of HbA1c revealed age and fasting glucose as independent predictors in each study group, with the addition of WHR in Aboriginal Australians. CONCLUSION: The notable finding was that waist or WHR are preferred obesity measures to appropriately reflect cardiometabolic risk in Aboriginal Australians, who although leaner by BMI criteria, displayed a similarly adverse risk profile to Aboriginal Canadians. Waist or WHR should be routinely included in clinical assessment in these high-risk populations.
File Format	HTM / HTML
ISSN	01688227
Issue Number	1
Volume Number	100
e-ISSN	18728227
Journal	Diabetes Research and Clinical Practice
Language	English
Publisher	Elsevier
Publisher Date	2013-04-01
Publisher Place	Ireland
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Research Support, Non-u.s. Gov't Cardiovascular Diseases Prevalence Dyslipidemias Area Under Curve Anthropometry Humans Middle Aged Cholesterol, Ldl Male Epidemiology Blood Journal Article Cholesterol, Hdl Questionnaires Adult Female Diabetes Mellitus, Type 2 Body Mass Index Glucose Tolerance Test Prevention & Control Hemoglobin A, Glycosylated Blood Glucose Ethnology Linear Models Metabolism Canada Discipline Endocrinology Multicenter Study Diabetic Angiopathies Australia
Content Type	Text
Resource Type	Article
Subject	Endocrinology, Diabetes and Metabolism Internal Medicine Endocrinology

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