NDLI: Serum irisin levels in new-onset type 2 diabetes.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Choi, Yeon-Kyung Kim, Mi-Kyung Bae, Kwi Hyun Seo, Hyun-Ae Jeong, Ji-Yun Lee, Won-Kee Kim, Jung-Guk Lee, In-Kyu Park, Keun-Gyu
Spatial Coverage	Republic of Korea
Description	Country affiliation: South Korea Author Affiliation: Choi YK ( Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, South Korea.)
Abstract	AIMS: Irisin has been identified as a novel myokine that drives brown-fat-like conversion of white adipose tissue. In this cross-sectional study, we investigated whether serum irisin levels are decreased in patients with type 2 diabetes (T2D) compared with control subjects with normal glucose tolerance (NGT), and assessed the association between serum irisin levels and various metabolic parameters. METHODS: The study population was selected from a population-based study and included 104 subjects with NGT and 104 subjects with new-onset T2D. Serum irisin and adiponectin levels and metabolic parameters were measured. Multivariate logistic regression analysis was performed to assess the association between irisin levels and newly diagnosed T2D. RESULTS: Serum irisin levels were significantly decreased in the new-onset T2D group compared with the NGT control group (p=0.003). In a multivariable model adjusted for various metabolic parameters, increased irisin levels were associated with reduced odds (OR 0.64, 95% CI 0.47-0.88, p=0.006) of prevalent newly diagnosed T2D. Furthermore, multiple regression analysis showed that 2 h plasma glucose was an independent variable influencing serum irisin levels (p=0.004). CONCLUSION: In the present study, we found that serum irisin levels were decreased in T2D patients and inversely associated with newly diagnosed T2D, suggesting that irisin may play a crucial role in glucose intolerance and T2D.
File Format	HTM / HTML
ISSN	01688227
Issue Number	1
Volume Number	100
e-ISSN	18728227
Journal	Diabetes Research and Clinical Practice
Language	English
Publisher	Elsevier
Publisher Date	2013-04-01
Publisher Place	Ireland
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Fibronectins Body Mass Index Obesity Research Support, Non-u.s. Gov't Cardiovascular Diseases Cross-sectional Studies Biological Markers Humans Logistic Models Male Epidemiology Blood Journal Article Adiponectin Physiopathology Republic Of Korea Thermogenesis Discipline Endocrinology Ppar Gamma Female Diabetes Mellitus, Type 2 Aged Transcription Factors Diabetic Angiopathies
Content Type	Text
Resource Type	Article
Subject	Endocrinology, Diabetes and Metabolism Internal Medicine Endocrinology

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