NDLI: Association of age and CKD with prognosis of myocardial infarction.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Choi, Joon Seok Kim, Min Jee Kang, Yong Un Kim, Chang Seong Bae, Eun Hui Ma, Seong Kwon Ahn, Young-Keun Jeong, Myung Ho Kim, Young Jo Cho, Myeong Chan Kim, Chong Jin Kim, Soo Wan
Spatial Coverage	Republic of Korea
Description	Author Affiliation: Choi JS ( Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.)
Abstract	BACKGROUND AND OBJECTIVES: CKD is a well known poor prognostic factor in myocardial infarction (MI). This study evaluated the prognostic significance of CKD, particularly in association with increasing age, in MI patients. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: This study was based on a retrospective cohort, the Korean Acute Myocardial Infarction Registry. Patients with a discharge diagnosis of MI were analyzed to investigate the association of CKD with mortality risk according to age. A total of 11,268 patients (mean age 63.0±12.6 years) were included and followed for 1 year. RESULTS: In the full cohort, 26% of patients had CKD (n=2929). The prevalence of CKD was higher with advancing age. Eight hundred sixty-one patients (7.6%) died and the interaction for 1-year mortality between age strata and estimated GFR (eGFR) strata was significant (P<0.001). Within each age category, the absolute 1-year mortality was higher in patients with a low eGFR. However, the adjusted relative mortality risk for a low eGFR was lower with increasing age (adjusted hazard ratio [95% confidence interval] for 1-year mortality at eGFR <30 ml/min per 1.73 m(2): 4.84 [1.93-12.15], 4.53 [2.42-8.47], 3.51 [2.42-5.09], and 3.30 [2.41-4.52] for patients aged <55, 55-64, 65-74, and ≥75 years compared with those with eGFR ≥60 ml/min per 1.73 m(2), respectively). CONCLUSIONS: For all age categories, the overall mortality was significantly higher as eGFR declined. The association of a lower eGFR with mortality was weaker with increasing age, indicating that the prognostic significance of CKD in MI patients is age dependent.
File Format	HTM / HTML
ISSN	15559041
e-ISSN	1555905X
DOI	10.2215/CJN.06930712
Journal	Clinical Journal of the American Society of Nephrology
Issue Number	6
Volume Number	8
Language	English
Publisher	American Society of Nephrology
Publisher Date	2013-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Chi-square Distribution Research Support, Non-u.s. Gov't Prognosis Comparative Study Patient Discharge Epidemiology Kidney Embryology Time Factors Registries Retrospective Studies Diagnosis Renal Insufficiency, Chronic Glomerular Filtration Rate Mortality Risk Factors Proportional Hazards Models Discipline Nephrology Physiopathology Myocardial Infarction
Content Type	Text
Resource Type	Article
Subject	Transplantation Critical Care and Intensive Care Medicine Nephrology Epidemiology

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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