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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Hu, X. Gao, J. Liao, Y. Tang, S. Lu, F. |
| Description | Author Affiliation: Hu X ( 1] Department of Plastic and Burn Surgery, Guangzhou Red Cross Hospital, Guangzhou 510220, People's Republic of China [2] Department of Plastic and Cosmetic Surgery, Nan Fang Hospital, Guangzhou 510515, People's Republic of China.) |
| Abstract | Retinoic acid (RA) contributes to cleft palate; however, the cellular and molecular mechanisms responsible for the deleterious effects on the developing palate are unclear. Wnt signaling is a candidate pathway in the cleft palate and is associated with RA in organ development; thus, we aim to investigate whether RA-induced cleft palate also results from altered Wnt signaling. Administration of RA to mice altered cell proliferation and apoptosis in craniofacial tissues by regulating molecules controlling cell cycle and p38 MAPK signaling, respectively. This altered cell fate by RA is a crucial mechanism contributing to 100% incidence of cleft palate. Moreover, Wnt/ß-catenin signaling was completely inhibited by RA in the early developing palate via its binding and activation with RA receptor (RAR) and is responsible for RA-induced cleft palate. Furthermore, PI3K/Akt signaling was also involved in actions of RA. Our findings help in elucidating the mechanisms of RA-induced cleft palate. |
| File Format | HTM / HTML |
| e-ISSN | 20414889 |
| DOI | 10.1038/cddis.2013.424 |
| Journal | Cell Death and Disease |
| Volume Number | 4 |
| Language | English |
| Publisher | Nature Publishing Group |
| Publisher Date | 2013-10-31 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Research Support, Non-u.s. Gov't Microscopy, Electron, Scanning Cell Proliferation Cell Survival Cytology Cells, Cultured Mesoderm Epithelial Cells Pharmacology Wnt Proteins Metabolism In Situ Nick-end Labeling Drug Effects Blotting, Western Beta Catenin Pregnancy Discipline Cell Biology Animals Cleft Palate Genetics Mice Tretinoin |
| Content Type | Text |
| Resource Type | Article |
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