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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ma, X. Shao, Y. Zheng, H. Li, M. Li, W. Xue, L. |
| Description | Country affiliation: China Author Affiliation: Ma X ( Department of Interventional Radiology, Shanghai Key Laboratory of Signaling and Disease Research, Shanghai 10th People's Hospital, School of Life Science and Technology, Tongji University, Shanghai 200092, China.) |
| Abstract | Loss of the cell polarity gene could cooperate with oncogenic Ras to drive tumor growth and invasion, which critically depends on the c-Jun N-terminal Kinase (JNK) signaling pathway in Drosophila. By performing a genetic screen, we have identified Src42A, the ortholog of mammalian Src, as a key modulator of both Ras(V12)/lgl(-/-) triggered tumor invasion and loss of cell polarity gene-induced cell migration. Our genetic study further demonstrated that the Bendless (Ben)/dUev1a ubiquitin E2 complex is an essential regulator of Src42A-induced, JNK-mediated cell migration. Furthermore, we showed that ectopic Ben/dUev1a expression induced invasive cell migration along with increased MMP1 production in wing disc epithelia. Moreover, Ben/dUev1a could cooperate with Ras(V12) to promote tumor overgrowth and invasion. In addition, we found that the Ben/dUev1a complex is required for ectopic Src42A-triggered cell death and endogenous Src42A-dependent thorax closure. Our data not only provide a mechanistic insight into the role of Src in development and disease but also propose a potential oncogenic function for Ubc13 and Uev1a, the mammalian homologs of Ben and dUev1a. |
| File Format | HTM / HTML |
| e-ISSN | 20414889 |
| DOI | 10.1038/cddis.2013.392 |
| Journal | Cell Death and Disease |
| Volume Number | 4 |
| Language | English |
| Publisher | Nature Publishing Group |
| Publisher Date | 2013-10-17 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Drosophila Proteins Research Support, Non-u.s. Gov't Neoplasm Invasiveness Cytology Metabolism Neoplasms Jnk Mitogen-activated Protein Kinases Proto-oncogene Proteins Pp60(c-src) Discipline Cell Biology Drosophila Melanogaster Pathology Growth & Development Neoplasm Metastasis Animals Ras Proteins Ubiquitin-conjugating Enzymes Cell Death Transcription Factors Enzyme Activation Map Kinase Signaling System Enzymology Cell Movement |
| Content Type | Text |
| Resource Type | Article |
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