NDLI: Controlled release behaviour and antibacterial effects of antibiotic-loaded titania nanotubes.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Feng, Wenchao Geng, Zhen Li, Zhaoyang Cui, Zhenduo Zhu, Shengli Liang, Yanqin Liu, Yunde Wang, Renfeng Yang, Xianjin
Description	Country affiliation: China Author Affiliation: Feng W ( School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China.); Geng Z ( School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China.); Li Z ( School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China); Cui Z ( School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China.); Zhu S ( School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China); Liang Y ( School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China.); Liu Y ( School of Laboratory Medicine, Tianjin Medical University, Tianjin, 300203, China.); Wang R ( School of Laboratory Medicine, Tianjin Medical University, Tianjin, 300203, China.); Yang X ( School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China)
Abstract	Bacterial infections have been identified as the main cause of orthopaedic implant failure. Owing to their high antibiotic delivery efficiency, titania nanotubes loaded with antibiotics constitute one of the most promising strategies for suppressing bacterial infections. However, it is difficult to control the drug-release behaviour of such nanotubes. Although sealing the nanotubes with a polymer solution provides sustained release effects to a certain extent, it inevitably influences their initial antibacterial activity. This study reports on the controlled release of gentamicin sulphate (GS) from titania nanotube surfaces whereby their initial antibacterial activity remains unaffected. Titania nanotubes were fabricated via electrochemical anodization and loaded with GS through physical adsorption. Experimental results showed that this loading method is feasible and efficient. The GS-loaded titania nanotubes were further covered by a thin film comprising a mixture of GS and chitosan (GSCH). The release kinetics confirmed that the drug release could be controlled by this thin film. Moreover, such a film was shown to not only inhibit initial bacterial adherence owing to its strong antibacterial properties but also enhance cell viability. Thus, GS-loaded titania nanotubes coated with GSCH have considerable potential as biomaterials for preventing initial release and peri-implant infection in the field of orthopaedics.
File Format	HTM / HTML
ISSN	09284931
Journal	Materials Science and Engineering: C
Volume Number	62
e-ISSN	18730191
Language	English
Publisher	Elsevier
Publisher Date	2016-05-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Content Type	Text
Resource Type	Article
Subject	Mechanics of Materials Biomaterials Condensed Matter Physics Bioengineering Mechanical Engineering

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