NDLI: Antibacterial ability and angiogenic activity of Cu-Ti-O nanotube arrays.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zong, Mingxiang Bai, Long Liu, Yanlian Wang, Xin Zhang, Xiangyu Huang, Xiaobo Hang, Ruiqiang Tang, Bin
Description	Country affiliation: China Author Affiliation: Zong M ( Research Institute of Surface Engineering, Taiyuan University of Technology, 030024 Taiyuan, China.); Bai L ( Research Institute of Surface Engineering, Taiyuan University of Technology, 030024 Taiyuan, China.); Liu Y ( Research Institute of Surface Engineering, Taiyuan University of Technology, 030024 Taiyuan, China.); Wang X ( Research Institute of Surface Engineering, Taiyuan University of Technology, 030024 Taiyuan, China.); Zhang X ( Research Institute of Surface Engineering, Taiyuan University of Technology, 030024 Taiyuan, China.); Huang X ( Research Institute of Surface Engineering, Taiyuan University of Technology, 030024 Taiyuan, China.); Hang R ( Research Institute of Surface Engineering, Taiyuan University of Technology, 030024 Taiyuan, China. Electronic address: hangruiqiang@tyut.edu.cn.); Tang B ( Research Institute of Surface Engineering, Taiyuan University of Technology, 030024 Taiyuan, China.)
Abstract	Bacterial infection and loosening of orthopedic implants remain two disastrously postoperative complications. Angiogenesis is critical important to facilitate implant osseointegration in vivo. TiO nanotubes arrays (NTAs) with proper dimensions possess good osseointegration ability. Accordingly, the present work incorporated copper (Cu) into TiO NTAs (Cu-Ti-O NTAs) to enhance their antibacterial ability and angiogenesis activity, which was realized through anodizing magnetron-sputtered TiCu coatings with different Cu contents on pure titanium (Ti). Our results show ordered Cu-Ti-O NTAs can be produced under proper Cu content (<15.14%) in TiCu coatings. The NTAs possess excellent long-term antibacterial ability against Staphylococcus aureus (S. aureus), which may be ascribed to sustained release of Cu . The cytotoxicity of Cu-Ti-O NTAs to endothelial cells (ECs) could be negligible and can even promote cell proliferation as revealed by live/dead staining and MTT. Meanwhile, Cu-Ti-O NTAs can up-regulate nitric oxide (NO) synthesis and vascular endothelial growth factors (VEGF) secretion of ECs on the sample surfaces compared with that of pure TiO NTAs (control). Furthermore, the angiogenic activity is also enhanced in ionic extracts of Cu-Ti-O NTAs compared with the control. The excellent long-term antibacterial ability and favorable angiogenic activity render Cu-Ti-O NTAs to be promising implant coatings.
File Format	HTM / HTML
ISSN	09284931
Journal	Materials Science and Engineering: C
Volume Number	71
e-ISSN	18730191
Language	English
Publisher	Elsevier
Publisher Date	2017-02-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Content Type	Text
Resource Type	Article
Subject	Mechanics of Materials Biomaterials Condensed Matter Physics Bioengineering Mechanical Engineering

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