NDLI: Multinodular/plexiform (multifascicular) schwannomas of major peripheral nerves: an underrecognized part of the spectrum of schwannomas.

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Year: 2010 Volume: 112 Issue: 1

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Multinodular/plexiform (multifascicular) schwannomas of major peripheral nerves: an underrecognized part of the spectrum of schwannomas.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Hébert-Blouin, Marie-Noëlle Amrami, Kimberly K. Scheithauer, Bernd W. Spinner, Robert J.
Description	Country affiliation: United States Author Affiliation: Hébert-Blouin MN ( Department of Neurosurgery, Mayo Clinic, Rochester, Minnesota 55905, USA.)
Abstract	OBJECT: In clinical practice, schwannomas are among the most common types of nerve sheath tumors. Their clinical presentation, imaging characteristics, and operative features are well known. Over the past 20 years, clinical outcomes have improved due to resection of these tumors at a fascicular level. Despite these advances, a subgroup of patients with schwannomas is associated with a disappointing neurological outcome following resection. The purpose of this study was to correlate the imaging and histological features in this group of patients with more anatomically complex forms of schwannomas. METHODS: In a retrospective review performed at their institution over a 10-year period, the authors found a subgroup of patients with complex multinodular/plexiform schwannomas affecting major peripheral nerves. Eleven patients were identified, and the clinical, imaging, and pathological features of their disease were reviewed. RESULTS: The clinical presentation of multinodular/plexiform schwannomas of major peripheral nerves may be similar to that of conventional schwannomas, but their imaging features, operative appearance, and outcomes differ. CONCLUSIONS: Preoperatively and intraoperatively, the distinguishing features of multinodular/plexiform schwannomas of major peripheral nerves may be subtle and can easily go unrecognized, thus explaining the often suboptimal surgical results. Familiarity with the imaging and operative features of multinodular/plexiform schwannomas will no doubt alter treatment approaches and improve neurological function in this subgroup of patients.
File Format	HTM / HTML
ISSN	00223085
e-ISSN	19330693
Journal	Journal of Neurosurgery
Issue Number	2
Volume Number	112
Language	English
Publisher	American Association of Neurological Surgeons
Publisher Date	2010-02-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Neurosurgery Neurilemmoma Pathology Surgery Peripheral Nervous System Neoplasms Infant Magnetic Resonance Imaging Therapy Peripheral Nerves Retrospective Studies
Content Type	Text
Resource Type	Article
Subject	Neurology (clinical) Surgery

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