NDLI: Localization of bone marrow stromal cells to the injury site after intracerebral hemorrhage in rats.

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Year: 2010 Volume: 112 Issue: 1

Year: 2009 Volume: 111

Localization of bone marrow stromal cells to the injury site after intracerebral hemorrhage in rats.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Seyfried, Donald M. Han, Yuxia Yang, Dongmei Ding, Jennifer Shen, Li Hong Savant-Bhonsale, Smita Chopp, Michael
Description	Country affiliation: United States Author Affiliation: Seyfried DM ( Department of Neurosurgery, Henry Ford Health System, Detroit, Michigan, USA.)
Abstract	OBJECT: Previous studies demonstrated that intravascular injection of bone marrow stromal cells (BMSCs) significantly improved neurological functional recovery in a rat model of intracerebral hemorrhage (ICH). To further investigate the fate of transplanted cells, we examined the effect of male rat BMSCs administered to female rats after ICH. METHODS: Twenty-seven female Wistar rats were subjected to ICH surgery. At 24 hours after ICH, these rats were randomly divided into 3 groups and injected intravenously with 1 ml phosphate-buffered saline or 0.5 million or 1 million male rat BMSCs in phosphate-buffered saline. To evaluate the neurological functional outcome, each rat was subjected to a series of behavioral tests (modified neurological severity score and corner turn test) at 1, 7, and 14 days after ICH. The rats were anesthetized intraperitoneally and killed, and the brain tissues were processed at Day 14 after ICH. Immunohistochemistry and in situ hybridization were used to identify cell-specific markers. RESULTS: The male rat BMSCs significantly improved the neurological functional outcome and also significantly diminished tissue loss when intravenously transplanted into the rats after ICH. Immunoassay for bromodeoxyuridine (BrdU) and neuronal markers demonstrated a significant increase in the number of BrdU-positive cells, which indicated endogenous neurogenesis, and a significant increase in the number of cells positive for immature neuronal markers. In situ hybridization showed that more BMSCs resided around the hematoma of the rats treated with the 1-million-cell dose compared with the 0.5-million-cell-dose group. In addition, a subfraction of Y chromosome-positive cells were co-immunostained with the neuronal marker microtubule-associated protein-2 or the astrocytic marker glial fibrillary acidic protein. CONCLUSIONS: Male rat BMSCs improve neurological outcome and increase histochemical parameters of neurogenesis when administered to female rats after ICH. This study has shown that the intravenously administered male rat BMSCs enter the brain, migrate to the perihematomal area, and express parenchymal markers.
File Format	HTM / HTML
ISSN	00223085
e-ISSN	19330693
DOI	10.3171/2009.2.JNS08907
Journal	Journal of Neurosurgery
Issue Number	2
Volume Number	112
Language	English
Publisher	American Association of Neurological Surgeons
Publisher Date	2010-02-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Neurosurgery Bone Marrow Transplantation Cerebral Hemorrhage Physiopathology Surgery Stromal Cells Transplantation Animals Astrocytes Physiology Cell Movement Disease Models, Animal Hematoma Injections, Intravenous Neurogenesis Neurons Random Allocation Rats, Wistar Time Factors Research Support, N.i.h., Extramural
Content Type	Text
Resource Type	Article
Subject	Neurology (clinical) Surgery

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Bone Marrow Stromal Cells Localize to the Injury Site after Intracerebral Hemorrhage in Rats

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