NDLI: Lateral hypothalamic area deep brain stimulation for refractory obesity: a pilot study with preliminary data on safety, body weight, and energy metabolism.

Please wait, while we are loading the content...

Prevention of postoperative cerebrospinal fluid leaks with multilayered reconstruction using titanium mesh-hydroxyapatite cement cranioplasty after translabyrinthine resection of acoustic neuroma.

Durability of hearing preservation after microsurgical treatment of vestibular schwannoma using the middle cranial fossa approach.

Modern surgical outcomes following surgery for sphenoid wing meningiomas.

Vestibular schwannomas in the modern era: epidemiology, treatment trends, and disparities in management.

Ophthalmic vein compression for selected benign low-flow cavernous sinus dural arteriovenous fistulas.

Colocalization of thin-walled dome regions with low hemodynamic wall shear stress in unruptured cerebral aneurysms.

Infarction of the lateral posterior choroidal artery territory after manipulation of the choroid plexus at the atrium: causal association with subependymal artery injury.

Lateral hypothalamic area deep brain stimulation for refractory obesity: a pilot study with preliminary data on safety, body weight, and energy metabolism.

Molecular oncogenesis of craniopharyngioma: current and future strategies for the development of targeted therapies.

In vivo embolization of lateral wall aneurysms in canines using the liquid-to-solid gelling PPODA-QT polymer system: 6-month pilot study.

Pathomorphometry of ruptured intracranial vertebral arterial dissection: adventitial rupture, dilated lesion, intimal tear, and medial defect.

Interactive presurgical simulation applying advanced 3D imaging and modeling techniques for skull base and deep tumors.

Infundibular widening mimicking anterior communicating artery aneurysm: report of 2 cases.

Fast presurgical functional mapping using task-related intracranial high gamma activity.

Early and long-term excess mortality in 227 patients with intracranial dural arteriovenous fistulas.

Functional mapping.

Barrow ruptured aneurysm trial.

Bone flap explantation, steroid use, and rates of infection in patients with epilepsy undergoing craniotomy for implantation of subdural electrodes.

Seizure surgery.

The Barrow Ruptured Aneurysm Trial: 3-year results.

Long-term seizure, cognitive, and psychiatric outcome following trans-middle temporal gyrus amygdalohippocampectomy and standard temporal lobectomy.

Enlargement of small, asymptomatic, unruptured intracranial aneurysms in patients with no history of subarachnoid hemorrhage: the different factors related to the growth of single and multiple aneurysms.

Radiation exposure in patients with subarachnoid hemorrhage: a quality improvement target.

Seizure outcome in surgically treated drug-resistant mesial temporal lobe epilepsy based on the recent histopathological classifications.

Dissociation of vasospasm-related morbidity and outcomes in patients with aneurysmal subarachnoid hemorrhage treated with clazosentan: a meta-analysis of randomized controlled trials.

Risk factor analysis of the development of new neurological deficits following supplementary motor area resection.

Supplementary motor resections.

Addendum: Evidence supports a 'no-touch' approach to neuromuscular choristoma.

Treatment of a carotid cavernous fistula via direct transovale cavernous sinus puncture.

Intraoperative neurophysiological monitoring of extracranial-intracranial bypass procedures.

Impact of global cerebral atrophy on clinical outcome after subarachnoid hemorrhage.

Medulloblastoma and the inferior medullary velum.

Year: 2013 Volume: 119 Issue: Supplementary

Year: 2013 Volume: 118

Year: 2012 Volume: 117

Year: 2012 Volume: 116

Year: 2011 Volume: 115

Year: 2011 Volume: 114

Year: 2010 Volume: 113

Year: 2010 Volume: 112

Year: 2009 Volume: 111

Lateral hypothalamic area deep brain stimulation for refractory obesity: a pilot study with preliminary data on safety, body weight, and energy metabolism.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Whiting, Donald M. Tomycz, Nestor D. Bailes, Julian de Jonge, Lilian Lecoultre, Virgile Wilent, Bryan Alcindor, Dunbar Prostko, E. Richard Cheng, Boyle C. Angle, Cynthia Cantella, Diane Whiting, Benjamin B. Mizes, J. Scott Finnis, Kirk W. Ravussin, Eric Oh, Michael Y.
Description	Country affiliation: United States Author Affiliation: Whiting DM ( Department of Neurosurgery, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212, USA.)
Abstract	OBJECT: Deep brain stimulation (DBS) of the lateral hypothalamic area (LHA) has been suggested as a potential treatment for intractable obesity. The authors present the 2-year safety results as well as early efficacy and metabolic effects in 3 patients undergoing bilateral LHA DBS in the first study of this approach in humans. METHODS: Three patients meeting strict criteria for intractable obesity, including failed bariatric surgery, underwent bilateral implantation of LHA DBS electrodes as part of an institutional review board- and FDA-approved pilot study. The primary focus of the study was safety; however, the authors also received approval to collect data on early efficacy including weight change and energy metabolism. RESULTS: No serious adverse effects, including detrimental psychological consequences, were observed with continuous LHA DBS after a mean follow-up of 35 months (range 30-39 months). Three-dimensional nonlinear transformation of postoperative imaging superimposed onto brain atlas anatomy was used to confirm and study DBS contact proximity to the LHA. No significant weight loss trends were seen when DBS was programmed using standard settings derived from movement disorder DBS surgery. However, promising weight loss trends have been observed when monopolar DBS stimulation has been applied via specific contacts found to increase the resting metabolic rate measured in a respiratory chamber. CONCLUSIONS: Deep brain stimulation of the LHA may be applied safely to humans with intractable obesity. Early evidence for some weight loss under metabolically optimized settings provides the first 'proof of principle' for this novel antiobesity strategy. A larger follow-up study focused on efficacy along with a more rigorous metabolic analysis is planned to further explore the benefits and therapeutic mechanism behind this investigational therapy.
File Format	HTM / HTML
ISSN	00223085
e-ISSN	19330693
Journal	Journal of Neurosurgery
Issue Number	1
Volume Number	119
Language	English
Publisher	American Association of Neurological Surgeons
Publisher Date	2013-07-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Neurosurgery Body Weight Deep Brain Stimulation Energy Metabolism Hypothalamic Area, Lateral Surgery Obesity Therapy Bariatric Surgery Body Image Adverse Effects Feeding Behavior Physiology Metabolism Psychology Pilot Projects Psychological Tests Tretoquinol Clinical Trial Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Neurology (clinical) Surgery

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Mapping of microstimulation evoked responses and unit activity patterns in the lateral hypothalamic area recorded in awake humans. Technical note.

Deep brain stimulation for obesity--from theoretical foundations to designing the first human pilot study.

A multicenter pilot study of subcallosal cingulate area deep brain stimulation for treatment-resistant depression.

Deep brain stimulation for obesity control: analyzing stimulation parameters to modulate energy expenditure.

Self-stimulation and body weight in rats with lateral hypothalamic lesions.

Deep brain stimulation and seizures.

Deep brain stimulation of the ventral anterior limb of the capsula interna in patients with treatment-refractory anorexia nervosa

Cognitive function predicts weight loss after bariatric surgery.

Headache as a Presenting Symptom of Deep Brain Stimulator Generator Failure.

Lateral hypothalamic area deep brain stimulation for refractory obesity: a pilot study with preliminary data on safety, body weight, and energy metabolism.

Similar Documents

Mapping of microstimulation evoked responses and unit activity patterns in the lateral hypothalamic area recorded in awake humans. Technical note.

Deep brain stimulation for obesity--from theoretical foundations to designing the first human pilot study.

A multicenter pilot study of subcallosal cingulate area deep brain stimulation for treatment-resistant depression.

Deep brain stimulation for obesity control: analyzing stimulation parameters to modulate energy expenditure.

Self-stimulation and body weight in rats with lateral hypothalamic lesions.

Deep brain stimulation and seizures.

Deep brain stimulation of the ventral anterior limb of the capsula interna in patients with treatment-refractory anorexia nervosa

Cognitive function predicts weight loss after bariatric surgery.

Headache as a Presenting Symptom of Deep Brain Stimulator Generator Failure.

Lateral hypothalamic area deep brain stimulation for refractory obesity: a pilot study with preliminary data on safety, body weight, and energy metabolism.