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Self-stimulation and body weight in rats with lateral hypothalamic lesions.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Keesey, Richard E. Powley, T. L. |
| Copyright Year | 1973 |
| Abstract | KEESEY, RICHARD E., AND TERRY L. POWLEY. Self-stimulation and body weight in rats with lateral hypothalamic lesions. Am. J. Physiol. 224(4) : 970-978. 1973.-Electrical self-stimulation of the posterior hypothalamus and ventral tegmentum was either eliminated or severely depressed in male rats following placement of lateral hypothalamic lesions. Though the rate of responding increased over the next 2-3 weeks, the terminal level of self-stimulation (expressed as a proportion of the stable postlesion to prelesion rate) averaged only 55y0 and was inversely related to the extent of lateral hypothalamic destruction (Y = -. 79). Body weight also declined in the postlesion period and a new maintenance level (83% of normal) was reached in the third postlesion week. This reduced level of weight maintenance was also inversely related to the percentage of lateral hypothalamic damage (Y = .86) and directly related to the chronic reduction in selfstimulation rate (Y = +. 79). A model relating central reward to the regulation of body weight is discussed. |
| Starting Page | 25 |
| Ending Page | 34 |
| Page Count | 10 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://ajplegacy.physiology.org/content/224/4/970?ijkey=428dfe092995ccb456b9b42d76b0db4e677c7d55&keytype2=tf_ipsecsha |
| PubMed reference number | 4698814v1 |
| Volume Number | 224 |
| Issue Number | 4 |
| Journal | The American journal of physiology |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Depressive disorder Hypothalamic Area, Lateral Hypothalamic Hormones Hypothalamic structure Phase II/III Trial Posterior Hypothalamic Region Seventy Nine Tegmentum Mesencephali |
| Content Type | Text |
| Resource Type | Article |
