NDLI: Colocalization of thin-walled dome regions with low hemodynamic wall shear stress in unruptured cerebral aneurysms.

Please wait, while we are loading the content...

Prevention of postoperative cerebrospinal fluid leaks with multilayered reconstruction using titanium mesh-hydroxyapatite cement cranioplasty after translabyrinthine resection of acoustic neuroma.

Durability of hearing preservation after microsurgical treatment of vestibular schwannoma using the middle cranial fossa approach.

Modern surgical outcomes following surgery for sphenoid wing meningiomas.

Vestibular schwannomas in the modern era: epidemiology, treatment trends, and disparities in management.

Ophthalmic vein compression for selected benign low-flow cavernous sinus dural arteriovenous fistulas.

Colocalization of thin-walled dome regions with low hemodynamic wall shear stress in unruptured cerebral aneurysms.

Infarction of the lateral posterior choroidal artery territory after manipulation of the choroid plexus at the atrium: causal association with subependymal artery injury.

Lateral hypothalamic area deep brain stimulation for refractory obesity: a pilot study with preliminary data on safety, body weight, and energy metabolism.

Molecular oncogenesis of craniopharyngioma: current and future strategies for the development of targeted therapies.

In vivo embolization of lateral wall aneurysms in canines using the liquid-to-solid gelling PPODA-QT polymer system: 6-month pilot study.

Pathomorphometry of ruptured intracranial vertebral arterial dissection: adventitial rupture, dilated lesion, intimal tear, and medial defect.

Interactive presurgical simulation applying advanced 3D imaging and modeling techniques for skull base and deep tumors.

Infundibular widening mimicking anterior communicating artery aneurysm: report of 2 cases.

Fast presurgical functional mapping using task-related intracranial high gamma activity.

Early and long-term excess mortality in 227 patients with intracranial dural arteriovenous fistulas.

Functional mapping.

Barrow ruptured aneurysm trial.

Bone flap explantation, steroid use, and rates of infection in patients with epilepsy undergoing craniotomy for implantation of subdural electrodes.

Seizure surgery.

The Barrow Ruptured Aneurysm Trial: 3-year results.

Long-term seizure, cognitive, and psychiatric outcome following trans-middle temporal gyrus amygdalohippocampectomy and standard temporal lobectomy.

Enlargement of small, asymptomatic, unruptured intracranial aneurysms in patients with no history of subarachnoid hemorrhage: the different factors related to the growth of single and multiple aneurysms.

Radiation exposure in patients with subarachnoid hemorrhage: a quality improvement target.

Seizure outcome in surgically treated drug-resistant mesial temporal lobe epilepsy based on the recent histopathological classifications.

Dissociation of vasospasm-related morbidity and outcomes in patients with aneurysmal subarachnoid hemorrhage treated with clazosentan: a meta-analysis of randomized controlled trials.

Risk factor analysis of the development of new neurological deficits following supplementary motor area resection.

Supplementary motor resections.

Addendum: Evidence supports a 'no-touch' approach to neuromuscular choristoma.

Treatment of a carotid cavernous fistula via direct transovale cavernous sinus puncture.

Intraoperative neurophysiological monitoring of extracranial-intracranial bypass procedures.

Impact of global cerebral atrophy on clinical outcome after subarachnoid hemorrhage.

Medulloblastoma and the inferior medullary velum.

Year: 2013 Volume: 119 Issue: Supplementary

Year: 2013 Volume: 118

Year: 2012 Volume: 117

Year: 2012 Volume: 116

Year: 2011 Volume: 115

Year: 2011 Volume: 114

Year: 2010 Volume: 113

Year: 2010 Volume: 112

Year: 2009 Volume: 111

Colocalization of thin-walled dome regions with low hemodynamic wall shear stress in unruptured cerebral aneurysms.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kadasi, Laith M. Dent, Walter C. Malek, Adel M.
Description	Country affiliation: United States Author Affiliation: Kadasi LM ( Cerebrovascular and Endovascular Division, Department of Neurosurgery, Tufts Medical Center, Boston, MA 02111, USA.)
Abstract	OBJECT: Wall shear stress (WSS) plays a role in regulating endothelial function and has been suspected in cerebral aneurysm rupture. The aim of this study was to evaluate the spatial relationship between localized thinning of the aneurysm dome and estimated hemodynamic factors, hypothesizing that a low WSS would correlate with aneurysm wall degeneration. METHODS: Steady-state computational fluid dynamics analysis was performed on 16 aneurysms in 14 patients based on rotational angiographic volumes to derive maps of WSS, its spatial gradient (WSSG), and pressure. Local dome thickness was estimated categorically based on tissue translucency from high-resolution intraoperative microscopy findings. Each computational model was oriented to match the corresponding intraoperative view and numerically sampled in thin and normal adjacent dome regions, with controls at the neck and parent vessel. The pressure differential was computed as the difference between aneurysm dome points and the mean neck pressure. Pulsatile time-dependent confirmatory analysis was carried out in 7 patients. RESULTS: Matched-pair analysis revealed significantly lower levels of WSS (0.381 Pa vs 0.816 Pa; p<0.0001) in thin-walled dome areas than in adjacent baseline thickness regions. Similarly, log WSSG and log WSS×WSSG were both lower in thin regions (both p<0.0001); multivariate logistic regression analysis identified lower WSS and higher pressure differential as independent correlates of lower wall thickness with an area under the curve of 0.80. This relationship was observed in both steady-state and time-dependent pulsatile analyses. CONCLUSIONS: Thin-walled regions of unruptured cerebral aneurysms colocalize with low WSS, suggesting a cellular mechanotransduction link between areas of flow stasis and aneurysm wall thinning.
File Format	HTM / HTML
ISSN	00223085
e-ISSN	19330693
Journal	Journal of Neurosurgery
Issue Number	1
Volume Number	119
Language	English
Publisher	American Association of Neurological Surgeons
Publisher Date	2013-07-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Neurosurgery Cerebral Arteries Cerebrovascular Circulation Physiology Hemodynamics Intracranial Aneurysm Physiopathology Cerebral Angiography Surgery Logistic Models Matched-pair Analysis Models, Cardiovascular Multivariate Analysis Predictive Value Of Tests Pulsatile Flow Stress, Mechanical Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Neurology (clinical) Surgery

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Basic Principles of Hemodynamics and Cerebral Aneurysms.

Hemodynamic analysis of growing intracranial aneurysms arising from a posterior inferior cerebellar artery.

Hemodynamics and bleb formation in intracranial aneurysms.

Thunderclap headache, reversible cerebral arterial vasoconstriction, and unruptured aneurysms.

Intracranial stents for aneurysms: mere scaffold or hemodynamic therapy?

Hemodynamic analysis of intracranial aneurysms with daughter blebs.

New method for retrospective study of hemodynamic changes before and after aneurysm formation in patients with ruptured or unruptured aneurysms

Hemodynamic differences between unruptured and ruptured intracranial aneurysms during observation.

Hemodynamic analysis for endovascular treatment in small unruptured intracranial aneurysms: a matched comparison study of flow diverter versus LVIS

Colocalization of thin-walled dome regions with low hemodynamic wall shear stress in unruptured cerebral aneurysms.

Similar Documents

Basic Principles of Hemodynamics and Cerebral Aneurysms.

Hemodynamic analysis of growing intracranial aneurysms arising from a posterior inferior cerebellar artery.

Hemodynamics and bleb formation in intracranial aneurysms.

Thunderclap headache, reversible cerebral arterial vasoconstriction, and unruptured aneurysms.

Intracranial stents for aneurysms: mere scaffold or hemodynamic therapy?

Hemodynamic analysis of intracranial aneurysms with daughter blebs.

New method for retrospective study of hemodynamic changes before and after aneurysm formation in patients with ruptured or unruptured aneurysms

Hemodynamic differences between unruptured and ruptured intracranial aneurysms during observation.

Hemodynamic analysis for endovascular treatment in small unruptured intracranial aneurysms: a matched comparison study of flow diverter versus LVIS

Colocalization of thin-walled dome regions with low hemodynamic wall shear stress in unruptured cerebral aneurysms.