NDLI: ERK involvement in resistance to apoptosis in keratinocytes with mutant keratin.

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ERK involvement in resistance to apoptosis in keratinocytes with mutant keratin.

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ERK involvement in resistance to apoptosis in keratinocytes with mutant keratin.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Russell, David Ross, Heike Lane, E. Birgitte
Description	Country affiliation: United kingdom Author Affiliation: Russell D ( CR UK Cell Structure Research Group, Division of Molecular Medicine, University of Dundee College of Life Sciences, Dundee, UK. d.russell@dundee.ac.uk)
Abstract	The consequences of cell stress induced by misfolded proteins are an important contributor to many human diseases. One such disease is epidermolysis bullosa simplex (EBS), caused by mutations in the structural proteins (keratins K5 or K14) of the proliferative compartment of the epidermis (basal keratinocyte layer), leading to cell fragility and blistering. In severe EBS, the mutation is associated with aggregates of nonfilamentous keratin protein, and cell lines carrying such mutations show a constitutively activated stress response. Analysis of the cellular mechanisms leading to cell breakdown on physical stress may point the way to mutation-independent therapeutic approaches to these incurable genetic disorders. We therefore subjected EBS cell lines, immortalized from patients with EBS, to an oscillating mechanical stress in assays designed to mimic the physical trauma that leads to cell breakdown in vivo. These experiments show that mechanical stress activates extracellular signal-regulated kinase (ERK) signaling in these cells, and that the keratin mutant cells also show a resistance to apoptosis following mechanical stress that is reversed by inhibiting ERK. The consequences of constitutive expression of large amounts of defective structural protein in a tissue cell must be properly understood for the development of safe and effective therapies for these disorders.
File Format	HTM / HTML
ISSN	0022202X
e-ISSN	15231747
Journal	Journal of Investigative Dermatology
Issue Number	3
Volume Number	130
Language	English
Publisher	Elsevier
Publisher Date	2010-03-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Dermatology Apoptosis Physiology Epidermolysis Bullosa Simplex Extracellular Signal-regulated Map Kinases Metabolism Keratin-14 Genetics Keratin-5 Keratinocytes Cytology 14-3-3 Proteins Blood Proteins Pharmacology Butadienes Cell Line, Transformed Cyclic Amp-dependent Protein Kinases Enzyme Inhibitors Pathology Antagonists & Inhibitors Intermediate Filaments Enzymology Map Kinase Signaling System Mutagenesis Nitriles Phosphorylation Proto-oncogene Proteins C-akt Rna, Small Interfering Stress, Mechanical Bcl-associated Death Protein Bcl-x Protein Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry Molecular Biology Dermatology

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