NDLI: A TGFbeta-responsive gene signature is associated with a subset of diffuse scleroderma with increased disease severity.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Sargent, Jennifer L. Milano, Ausra Bhattacharyya, Swati Varga, John Connolly, M. Kari Chang, Howard Y. Whitfield, Michael L.
Description	Country affiliation: United States Author Affiliation: Sargent JL ( Department of Genetics, Dartmouth Medical School, Hanover, New Hampshire 03755, USA.)
Abstract	Systemic sclerosis is a complex disease with widespread skin fibrosis and variable visceral organ involvement. Since transforming growth factor-beta (TGFbeta) has been implicated in driving fibrosis in systemic sclerosis, a mechanism-derived gene expression signature was used to assay TGFbeta-responsive gene expression in the skin of patients with systemic sclerosis (SSc). Primary dermal fibroblasts from patients with diffuse SSc (dSSc) and healthy controls were treated with TGFbeta, and the genome-wide gene expression was measured on DNA microarrays over a time course of 24 hours. Eight hundred and ninety-four probes representing 674 uniquely annotated genes were identified as TGFbeta responsive. Expression of the TGFbeta-responsive signature was examined in skin biopsies from 17 dSSc, seven limited SSc (lSSc), three morphea patients, and six healthy controls. The TGFbeta-responsive signature was expressed in 10 out of 17 dSSc skin biopsies, but was not found in lSSc, morphea, or healthy control biopsies. Expression of dSSC the TGFbeta-responsive signature stratifies patients into two major groups, one of which corresponds to the 'diffuse-proliferation' intrinsic subset that showed higher modified Rodnan skin score and a higher likelihood of scleroderma lung disease. The TGFbeta-responsive signature is found in only a subset of dSSc patients who could be targeted by specific therapies.
File Format	HTM / HTML
ISSN	0022202X
e-ISSN	15231747
DOI	10.1038/jid.2009.318
Journal	Journal of Investigative Dermatology
Issue Number	3
Volume Number	130
Language	English
Publisher	Elsevier
Publisher Date	2010-03-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Dermatology Dermis Pathology Fibroblasts Physiology Scleroderma, Diffuse Transforming Growth Factor Beta Genetics Biopsy Cell Division Cells, Cultured Drug Effects Gene Expression Regulation Genome, Human Lung Diseases Physiopathology Oligonucleotide Array Sequence Analysis Severity Of Illness Index Metabolism Pharmacology Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry Molecular Biology Dermatology

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A TGFβ-Responsive Gene Signature Is Associated with a Subset of Diffuse Scleroderma with Increased Disease Severity

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A TGFβ-Responsive Gene Signature Is Associated with a Subset of Diffuse Scleroderma with Increased Disease Severity

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A TGFbeta-responsive gene signature is associated with a subset of diffuse scleroderma with increased disease severity.