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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Pham-Ledard, Anne Prochazkova-Carlotti, Martina Laharanne, Elodie Vergier, Béatrice Jouary, Thomas Beylot-Barry, Marie Merlio, Jean-Philippe |
| Description | Country affiliation: France Author Affiliation: Pham-Ledard A ( Department of Histology and Molecular Pathology of Tumors, University Bordeaux 2, and Department of Dermatology, Hôpital Saint André, Bordeaux, France.) |
| Abstract | The identification of IFN regulatory factor 4 gene (IRF4) translocation in 8 out of 14 cases of cutaneous anaplastic large cell lymphomas (C-ALCLs) (Leukemia, 2009; 23(3):574-80) prompted us to study IRF4 locus status in different cutaneous T-cell lymphoma (CTCL) subtypes. Fluorescence in situ hybridization (FISH) was used with break-apart dual-color probes. Sixty samples from 54 patients were analyzed with 23 C-ALCL, 11 transformed mycosis fungoides (T-MF), 7 lymphomatoid papulosis (LyP), and 13 Sézary syndrome (SS) cases. IRF4 immunostaining was performed in 32 cases. We observed a split FISH signal pattern indicating a translocation at the IRF4 locus in 6 out of 23 C-ALCL (26%) and 2 out of 11 T-MF (18.2%) cases. Extra copies of the IRF4 locus were found in 4 out of 13 SS, 1 out of 11 T-MF, and 1 out of 23 C-ALCL cases, corresponding to either aneuploidy, chromosome 6 trisomy, or 6p partial gain. The IRF4 expression was not correlated with the presence of IRF4 alteration in C-ALCL or T-MF. Interestingly, IRF4 rearrangements define a subgroup of CD30-positive C-ALCL and T-MF cases. Conversely, T-MF cases with IRF4 rearrangements may correspond to the development of C-ALCL in MF patients and not to large cell transformation. Investigation of the biological pathways triggered by IRF4 rearrangements and/or expression in CTCL will provide a biological basis for IRF4-directed therapy. |
| File Format | HTM / HTML |
| ISSN | 0022202X |
| e-ISSN | 15231747 |
| Journal | Journal of Investigative Dermatology |
| Issue Number | 3 |
| Volume Number | 130 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2010-03-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Dermatology Cell Transformation, Neoplastic Genetics Gene Rearrangement Interferon Regulatory Factors Lymphoma, T-cell, Cutaneous Mycosis Fungoides Skin Neoplasms Antigens, Cd30 Metabolism Biopsy Chromosomes, Human, Pair 6 Dna Breaks Fluorescent Antibody Technique In Situ Hybridization, Fluorescence Pathology Ploidies Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Biochemistry Molecular Biology Dermatology |
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