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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kannan, Vivekanandan Gadamsetty, Deepak Rose, Madhankumar Maria, Stella Mustafa, Imran Khedkar, Anand Dave, Nitesh Arumugam, Muruganandam Iyer, Harish |
| Description | Country affiliation: India Author Affiliation: Kannan V ( Research and Development, 20th KM Hosur Road, Biocon Limited, Bangalore, India. vivekanandan.kannan@yahoo.co.in) |
| Abstract | A kinetic study of atosiban was conducted following repeated intravenous administration in Wistar rats. Sample analysis was performed using liquid chromatography-tandem mass spectrometry (LC-MS/MS) following full validation of an in-house method. Eptifibatide, a cyclic peptide, was used as an internal standard (IS). The analyte and internal standard were extracted using solid phase extraction (SPE) method. Chromatographic separation was carried out using an ACE C18 5 microm 50 mm x 4.6 mm column with gradient elution. Mass spectrometric detection was performed using TSQ Quantum ultra AM. The lower limit of quantification was 0.01 microg/ml when 100 microl rat plasma was used. Plasma concentrations of atosiban were measured at 0 (pre-dose), 2, 15, 30, 45, 60, 120 min at the dosage levels of 0.125 mg/kg (low dose), 0.250 mg/kg (mid dose), and 0.500 mg/kg (high dose), respectively. Atosiban plasma concentration measured at Day 1 showed mean peak atosiban concentration (C(max)) 0.40, 0.57, 1.95 microg/ml for low, mid and high dose treated animals and mean peak concentration on Day 28 was 0.41, 0.88, 1.31microg/ml on Day 28 for low, mid and high dose treated animals. |
| File Format | HTM / HTML |
| ISSN | 15700232 |
| Issue Number | 15-16 |
| Volume Number | 878 |
| e-ISSN | 1873376X |
| Journal | Journal of Chromatography B |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2010-05-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Analytical Chemistry Chromatography, Liquid Methods Hormone Antagonists Blood Tandem Mass Spectrometry Vasotocin Analogs & Derivatives Animals Drug Stability Female Administration & Dosage Chemistry Pharmacokinetics Injections, Intravenous Linear Models Peptides Analysis Rats Rats, Wistar Receptors, Oxytocin Antagonists & Inhibitors Reproducibility Of Results Sensitivity And Specificity Solid Phase Extraction Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine Analytical Chemistry Clinical Biochemistry Biochemistry |
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