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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Hansen, G. M. Skapura, D. Justice, M. J. |
| Description | Author Affiliation: Hansen GM ( Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030 USA.) |
| Abstract | Murine leukemia retroviruses (MuLVs) cause leukemia and lymphoma in susceptible strains of mice as a result of insertional mutation of cellular proto-oncogenes or tumor suppressor genes. Using a novel approach to amplify and sequence viral insertion sites, we have sequenced >200 viral insertion sites from which we identify >35 genes altered by viral insertion in four AKXD mouse strains. The class of genes most frequently altered are transcription factors, however, insertions are found near genes involved in signal transduction, cell cycle control, DNA repair, cell division, hematopoietic differentiation, and near many ESTs and novel loci. Many of these mutations identify genes that have not been implicated in cancer. By isolating nearly all the somatic viral insertion mutations contributing to disease in these strains we show that each AKXD strain displays a unique mutation profile, suggesting strain-specific susceptibility to mutations in particular genetic pathways. |
| File Format | HTM / HTML |
| ISSN | 10889051 |
| e-ISSN | 15495469 |
| Journal | Genome Research |
| Issue Number | 2 |
| Volume Number | 10 |
| Language | English |
| Publisher | Cold Spring Harbor Laboratory Press |
| Publisher Date | 2000-02-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Genetics Discipline Genomics Leukemia, Experimental Genetics Lymphoma Mutagenesis, Insertional Retroviridae Infections Tumor Virus Infections Animals Cell Transformation, Neoplastic Leukemia Virus, Murine Virology Mice Mice, Inbred Strains Polymerase Chain Reaction Recombination, Genetic Terminal Repeat Sequences Research Support, Non-u.s. Gov't Research Support, U.s. Gov't, P.h.s. |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Genetics (clinical) |
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