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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Makrinou, E. Fox, M. Lovett, M. Haworth, K. Cameron, J. M. Taylor, K. Edwards, Y. H. |
| Description | Country affiliation: United kingdom Author Affiliation: Makrinou E ( MRC Human Biochemical Genetics Unit, University College London, Wolfson House, London NW1 2HE, UK.) |
| Abstract | Genes involved in human male sex determination and spermatogenesis are likely to be located on the Y chromosome. In an effort to identify Y-linked, testis-expressed genes, a cDNA selection library was generated by selecting testis cDNA with Y-cosmid clones. Resultant clones containing repetitive or vector material were eliminated, and 79 of the remaining clones were sequenced. Nineteen cDNAs showed homology with the TTY2 gene, and indicated that TTY2 is part of a large gene family. Screening of a panel of Y-linked cosmids revealed that the TTY2 gene family includes at least 26 members organized in 14 subfamilies. Further investigation revealed that TTY2 genes are arranged in tandemly arrayed clusters on both arms of the Y chromosome, and each gene comprises a series of tandemly arranged repeats. RT-PCR studies for two of these genes revealed that they are expressed in adult and fetal testis, as well as in the adult kidney. None of the genes investigated in detail contain an open reading frame. We conclude that the TTY2 gene family is composed of multiple copies, some of which may function as noncoding RNA transcripts and some may be pseudogenes. |
| File Format | HTM / HTML |
| ISSN | 10889051 |
| e-ISSN | 15495469 |
| Journal | Genome Research |
| Issue Number | 6 |
| Volume Number | 11 |
| Language | English |
| Publisher | Cold Spring Harbor Laboratory Press |
| Publisher Date | 2001-06-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Genetics Discipline Genomics Dna-binding Proteins Genetics Genetic Linkage Multigene Family Nuclear Proteins Transcription Factors Y Chromosome Animals Chromosome Mapping Biosynthesis Physiology Fetus Gene Library Gorilla Gorilla In Situ Hybridization, Fluorescence Molecular Sequence Data Pan Troglodytes Proteins Seminal Plasma Proteins Sequence Homology, Nucleic Acid Sex-determining Region Y Protein Tandem Repeat Sequences Testis Comparative Study |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Genetics (clinical) |
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