NDLI: Genomic organization of the sex-determining and adjacent regions of the sex chromosomes of medaka.

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Genomic organization of the sex-determining and adjacent regions of the sex chromosomes of medaka.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kondo, Mariko Hornung, Ute Nanda, Indrajit Imai, Shuichiro Sasaki, Takashi Shimizu, Atsushi Asakawa, Shuichi Hori, Hiroshi Schmid, Michael Shimizu, Nobuyoshi Schartl, Manfred
Description	Country affiliation: Germany Author Affiliation: Kondo M ( Department of Physiological Chemistry I, Biocenter, University of Wuerzburg, D-97074 Wuerzburg, Germany.)
Abstract	Sequencing of the human Y chromosome has uncovered the peculiarities of the genomic organization of a heterogametic sex chromosome of old evolutionary age, and has led to many insights into the evolutionary changes that occurred during its long history. We have studied the genomic organization of the medaka fish Y chromosome, which is one of the youngest heterogametic sex chromosomes on which molecular data are available. The Y specific and adjacent regions were sequenced and compared to the X. The male sex-determining gene, dmrt1bY, appears to be the only functional gene in the Y-specific region. The Y-specific region itself is derived from the duplication of a 43-kb fragment from linkage group 9. All other coduplicated genes except dmrt1bY degenerated. The Y-specific region has accumulated large stretches of repetitive sequences and duplicated pieces of DNA from elsewhere in the genome, thereby growing to 258 kb. Interestingly the non-recombining part of the Y did not spread out considerably from the original duplicated fragment, possibly because of a large sequence duplication bordering the Y-specific fragment. This may have conserved the more ancestral structure of the medaka Y and provides insights into some of the initial processes of Y chromosome evolution.
File Format	HTM / HTML
ISSN	10889051
e-ISSN	15495469
Journal	Genome Research
Issue Number	7
Volume Number	16
Language	English
Publisher	Cold Spring Harbor Laboratory Press
Publisher Date	2006-07-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Genetics Discipline Genomics Genome Oryzias Genetics Sex Chromosomes Sex Determination Processes Y Chromosome Animals Chromosome Mapping Evolution, Molecular Gene Duplication Genetic Linkage Genetic Markers In Situ Hybridization, Fluorescence Molecular Sequence Data Repetitive Sequences, Nucleic Acid Sequence Analysis, Dna Sequence Homology, Nucleic Acid Transcription Factors X Chromosome Comparative Study Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Genetics Genetics (clinical)

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