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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Haaf, Thomas Shima, Akihiro Winkler, Christoph Shan, Zhihong Shimizu, Nobuyoshi Nanda, Indrajit Hornung, Ute Shimizu, Atsushi Asakawa, Shuichi Schartl, Manfred Schmid, Michael Kondo, Mariko |
| Description | Author Affiliation: Nanda I ( Institute for Human Genetics, Biocenter, University of Würzburg, D-97074 Würzburg, Germany.); |
| Abstract | The genes that determine the development of the male or female sex are known in Caenorhabditis elegans, Drosophila, and most mammals. In many other organisms the existence of sex-determining factors has been shown by genetic evidence but the genes are unknown. We have found that in the fish medaka the Y chromosome-specific region spans only about 280 kb. It contains a duplicated copy of the autosomal DMRT1 gene, named DMRT1Y. This is the only functional gene in this chromosome segment and maps precisely to the male sex-determining locus. The gene is expressed during male embryonic and larval development and in the Sertoli cells of the adult testes. These features make DMRT1Y a candidate for the medaka male sex-determining gene. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 18 |
| Volume Number | 99 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2002-09-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Oryzias Genetics Sex Determination Processes Transcription Factors Y Chromosome Amino Acid Sequence Animals Chromosomes, Artificial, Bacterial Cloning, Molecular DNA Primers In Situ Hybridization, Fluorescence Molecular Sequence Data Sequence Homology, Amino Acid Chemistry Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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