NDLI: High intensity interval training favourably affects antioxidant and inflammation mRNA expression in early-stage chronic kidney disease.

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High intensity interval training favourably affects antioxidant and inflammation mRNA expression in early-stage chronic kidney disease.

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High intensity interval training favourably affects antioxidant and inflammation mRNA expression in early-stage chronic kidney disease.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Tucker, Patrick S. Briskey, David R. Scanlan, Aaron T. Coombes, Jeff S. Dalbo, Vincent J.
Description	Author Affiliation: Tucker PS ( Clinical Biochemistry Laboratory, Bruce Highway, Building 81, Central Queensland University, Rockhampton, Australia 4702); Briskey DR ( Antioxidant Research Group, Room 535, Human Movement and Nutrition Sciences Building, University of Queensland, Brisbane, Australia 4072. Electronic address: d.briskey@uq.edu.au.); Scanlan AT ( Clinical Biochemistry Laboratory, Bruce Highway, Building 81, Central Queensland University, Rockhampton, Australia 4702); Coombes JS ( Antioxidant Research Group, Room 535, Human Movement and Nutrition Sciences Building, University of Queensland, Brisbane, Australia 4072. Electronic address: jcoombes@uq.edu.au.); Dalbo VJ ( Clinical Biochemistry Laboratory, Bruce Highway, Building 81, Central Queensland University, Rockhampton, Australia 4702)
Abstract	Increased levels of oxidative stress and inflammation have been linked to the progression of chronic kidney disease. To reduce oxidative stress and inflammation related to chronic kidney disease, chronic aerobic exercise is often recommended. Data suggests high intensity interval training may be more beneficial than traditional aerobic exercise. However, appraisals of differing modes of exercise, along with explanations of mechanisms responsible for observed effects, are lacking. This study assessed effects of eight weeks of high intensity interval training (85% VO2max), versus low intensity exercise (45-50% VO2max) and sedentary behaviour, in an animal model of early-stage chronic kidney disease. We examined kidney-specific mRNA expression of genes related to endogenous antioxidant enzyme activity (glutathione peroxidase 1; Gpx1, superoxide dismutase 1; Sod1, and catalase; Cat) and inflammation (kidney injury molecule 1; Kim1 and tumour necrosis factor receptor super family 1b; Tnfrsf1b), as well as plasma F2-isoprostanes, a marker of lipid peroxidation. Compared to sedentary behaviour, high intensity interval training resulted in increased mRNA expression of Sod1 (p=0.01) and Cat (p<0.001). Compared to low intensity exercise, high intensity interval training resulted in increased mRNA expression of Cat (p<0.001) and Tnfrsf1b (p=0.047). In this study, high intensity interval training was superior to sedentary behaviour and low intensity exercise as high intensity interval training beneficially influenced expression of genes related to endogenous antioxidant enzyme activity and inflammation.
File Format	HTM / HTML
ISSN	08915849
Volume Number	89
e-ISSN	18734596
Journal	Free Radical Biology and Medicine
Language	English
Publisher	Elsevier
Publisher Date	2015-12-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Free radicals biology Antioxidants Metabolism Inflammation Physical Conditioning, Animal Methods Physiology Renal Insufficiency, Chronic Animals Disease Models, Animal Gas Chromatography-mass Spectrometry Gene Expression Male Oxidative Stress Rna, Messenger Analysis Rats Rats, Inbred Shr Reverse Transcriptase Polymerase Chain Reaction Transcriptome Journal Article
Content Type	Text
Resource Type	Article
Subject	Physiology (medical) Biochemistry

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