| Content Provider |
World Health Organization (WHO)-Global Index Medicus |
| Author |
Koh, Jin Sin Yi, Chin-ok Heo, Rok Won Ahn, Jong-Wha Park, Jeong Rang Lee, Jung Eun Kim, Jung-Hwan Hwang, Jin-Yong Roh, Gu Seob |
| Description |
Author Affiliation: Koh JS ( Division of Cardiology, Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju 660-751, Republic of Korea.); Yi CO ( Department of Anatomy and Convergence Medical Science, Institute of Health Sciences, Gyeongsang National University School of Medicine, Jinju 660-751, Republic of Korea.); Heo RW ( Department of Anatomy and Convergence Medical Science, Institute of Health Sciences, Gyeongsang National University School of Medicine, Jinju 660-751, Republic of Korea.); Ahn JW ( Division of Cardiology, Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju 660-751, Republic of Korea.); Park JR ( Division of Cardiology, Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju 660-751, Republic of Korea.); Lee JE ( Department of Thoracic and Cardiovascular Surgery, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju 660-751, Republic of Korea.); Kim JH ( Department of Pharmacology, Institute of Health Sciences, Gyeongsang National University School of Medicine,Jinju 660-751, Republic of Korea.); Hwang JY ( Division of Cardiology, Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju 660-751, Republic of Korea. Electronic address: jyhwang@gnu.ac.kr.); Roh GS ( Department of Anatomy and Convergence Medical Science, Institute of Health Sciences, Gyeongsang National University School of Medicine, Jinju 660-751, Republic of Korea. Electronic address: anaroh@gnu.ac.kr.) |
| Abstract |
Doxorubicin (Dox) is an effective anti-cancer drug, but its use is limited because of its adverse effect of inducing irreversible dilated cardiomyopathy. Cilostazol (Cilo), a potent phosphodiesterase III inhibitor, has been reported to have an anti-inflammatory effect. Here, we investigated whether Cilo has a protective effect against Dox-induced cardiomyopathy (DIC). Mice were randomly divided into four groups: saline control, Dox (15 mg/kg), Dox (15 mg/kg) plus Cilo (50mg/kg), and Cilo (50mg/kg). The results showed that the coadministration of Dox and Cilo significantly enhanced left-ventricular systolic function compared with Dox alone. In addition, Cilo treatment significantly reduced Dox-induced perivascular fibrosis, collagen concentration, and connective growth factor expression in the heart. Also, Cilo administration markedly reduced Dox-induced levels of serum B-type natriuretic peptide, dysferlin, high-mobility group protein B1, Toll-like receptor 4, nuclear factor-κB p65, and cyclooxygenase-2. Furthermore, Cilo treatment significantly reduced Dox-induced oxidative stress by lowering the translocation of Nrf2 into the nucleus and the expression of NQO1, heme oxygenase 1, and superoxide dismutase-1. Our results suggest that Cilo may be a potential antifibrotic, antioxidative, and anti-inflammatory drug for DIC. |
| File Format |
HTM / HTML |
| ISSN |
08915849 |
| Volume Number |
89 |
| e-ISSN |
18734596 |
| Journal |
Free Radical Biology and Medicine |
| Language |
English |
| Publisher |
Elsevier |
| Publisher Date |
2015-12-01 |
| Publisher Place |
United States |
| Access Restriction |
One Nation One Subscription (ONOS) |
| Subject Keyword |
Discipline Free radicals biology Cardiomyopathies Prevention & Control Doxorubicin Toxicity Fibrosis Inflammation Neuroprotective Agents Pharmacology Oxidative Stress Drug Effects Tetrazoles Animals Antibiotics, Antineoplastic Blotting, Western Chemically Induced Pathology Echocardiography Male Mice Mice, Inbred Icr Journal Article Research Support, Non-u.s. Gov't |
| Content Type |
Text |
| Resource Type |
Article |
| Subject |
Physiology (medical) Biochemistry |
