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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Tepaamorndech, Surapun Kirschke, Catherine P. Pedersen, Theresa L. Keyes, William R. Newman, John W. Huang, Liping |
| Description | Country affiliation: United States Author Affiliation: Tepaamorndech S ( Integrative Genetics and Genomics Graduate Group, University of California Davis, CA, USA.); Kirschke CP ( Obesity and Metabolism Research Unit, USDA/ARS/Western Human Nutrition Research Center, Davis, CA, USA.); Pedersen TL ( Obesity and Metabolism Research Unit, USDA/ARS/Western Human Nutrition Research Center, Davis, CA, USA.); Keyes WR ( Obesity and Metabolism Research Unit, USDA/ARS/Western Human Nutrition Research Center, Davis, CA, USA.); Newman JW ( Obesity and Metabolism Research Unit, USDA/ARS/Western Human Nutrition Research Center, Davis, CA, USA.); Huang L ( Department of Nutrition, University of California Davis, CA, USA.) |
| Abstract | Mice deficient for zinc transporter 7 protein (ZnT7) are mildly zinc deficient with low body weight gain and body fat accumulation. To investigate the underlying mechanism of ZnT7 deficiency in body adiposity, we examined fatty acid composition and insulin sensitivity in visceral (epididymal) and subcutaneous fat pads from Znt7 knockout and control mice. We showed that ZnT7 deficiency had adverse effects on fatty acid metabolism and insulin action in subcutaneous fat but not in epididymal fat in mice, consistent with the ZnT7 protein expression pattern in adipose tissues. Importantly, we found that the expression of ZnT7 protein was induced by lipogenic differentiation and reached a peak when the adipocyte was fully differentiated in mouse 3T3-L1 adipocytes. We demonstrated, using Znt7 knockdown (Znt7KD) 3T3-L1 adipocytes, that reduction in Znt7 expression blunted activations of the signal transduction pathways that regulated both basal and insulin-stimulated glucose uptake in adipocytes, resulting in low glucose uptake and lipid accumulation. The expression of the signaling mediators critical for the initiation of pre-adipocyte differentiation, including Pparγ and C/Ebp , appeared not to be affected by Znt7KD in 3T3-L1 adipocytes. These findings strongly suggest a role for ZnT7 in adipocyte lipogenesis. |
| File Format | HTM / HTML |
| ISSN | 1742464X |
| Issue Number | 2 |
| Volume Number | 283 |
| e-ISSN | 17424658 |
| Journal | FEBS Journal |
| Language | English |
| Publisher | Wiley (on behalf of the Federation of European Biochemical Societies) |
| Publisher Date | 2016-01-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry Adipocytes Metabolism Cation Transport Proteins Glucose Lipids Biosynthesis Proto-oncogene Proteins C-akt 3t3-l1 Cells Drug Effects Adipose Tissue Animals Body Weight Genetics Epididymis Fatty Acids Insulin Pharmacology Male Mice Mice, Inbred C57bl Mice, Knockout Subcutaneous Fat Journal Article Research Support, U.s. Gov't, Non-p.h.s. |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Biochemistry Molecular Biology |
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