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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Le Bourhis, Mikaël Rimbaud, Stéphanie Grebert, Denise Congar, Patrice Meunier, Nicolas |
| Description | Country affiliation: France Author Affiliation: Le Bourhis M ( Université d'Evry Val d'Essone, Evry, France) |
| Abstract | Several factors modulate the first step of odour detection in the rat olfactory mucosa (OM). Among others, vasoactive peptides such as endothelin might play multifaceted roles in the different OM cells. Like their counterparts in the central nervous system, the olfactory sensory neurons are encompassed by different glial-like non-neuronal OM cells; sustentacular cells (SCs) surround their cell bodies, whereas olfactory ensheathing cells (OECs) wrap their axons. Whereas SCs maintain both the structural and ionic integrity of the OM, OECs assure protection, local blood flow control and guiding of olfactory sensory neuron axons toward the olfactory bulb. We previously showed that these non-neuronal OM cells are particularly responsive to endothelin in vitro. Here, we confirmed that the endothelin system is strongly expressed in the OM using in situ hybridization. We then further explored the effects of endothelin on SCs and OECs using electrophysiological recordings and calcium imaging approaches on both in vitro and ex vivo OM preparations. Endothelin induced both robust calcium signals and gap junction uncoupling in both types of cells. This latter effect was mimicked by carbenoxolone, a known gap junction uncoupling agent. However, although endothelin is known for its antiapoptotic effect in the OM, the uncoupling of gap junctions by carbenoxolone was not sufficient to limit the cellular death induced by serum deprivation in OM primary culture. The functional consequence of the endothelin 1-induced reduction of the gap junctional communication between OM non-neuronal cells thus remains to be elucidated. |
| File Format | HTM / HTML |
| ISSN | 0953816X |
| Issue Number | 6 |
| Volume Number | 40 |
| e-ISSN | 14609568 |
| Journal | European Journal of Neuroscience |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2014-09-01 |
| Publisher Place | France |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Neuroscience Endothelins Metabolism Gap Junctions Physiology Neuroglia Olfactory Mucosa Sensory Receptor Cells Animals Calcium Carbenoxolone Pharmacology Cell Death Drug Effects Cells, Cultured Electric Stimulation Immunohistochemistry In Situ Hybridization L-lactate Dehydrogenase Male Optical Imaging Patch-clamp Techniques Rats, Wistar Sensory System Agents Tissue Culture Techniques Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neuroscience |
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