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Sequential onset of presynaptic molecules during olfactory sensory neuron maturation.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Marcucci, Florencia Zou, Dong-Jing Firestein, Stuart
Description	Country affiliation: United States Author Affiliation: Marcucci F ( Department of Biological Sciences, Columbia University, New York, New York 10027, USA.)
Abstract	Differentiated olfactory sensory neurons express specific presynaptic proteins, including enzymes involved in neurotransmitter transport and proteins involved in the trafficking and release of synaptic vesicles. Studying the regulation of these presynaptic proteins will help to elucidate the presynaptic differentiation process that ultimately leads to synapse formation. It has been postulated that the formation of a synapse between the axons of the sensory neurons and the dendrites of second order neurons in the olfactory bulb is a critical step in the processes of sensory neuron maturation. One approach to study the relationship between synaptogenesis and sensory neuron maturation is to examine the expression patterns of synaptic molecules through the olfactory neuron lineage. To this end we designed specific in situ hybridization probes to target messengers for proteins involved in presynaptic vesicle release. Our findings show that, as they mature, mouse olfactory neurons sequentially express specific presynaptic genes. Furthermore, the different patterns of expression of these presynaptic genes suggest the existence of discrete steps in presynaptic development: genes encoding proteins involved in scaffolding show an early onset of expression, whereas expression of genes encoding proteins involved in the regulation of vesicle release starts later. In particular, the signature molecule for glutamatergic neurons vesicle glutamate transporter 2 shows the latest onset of expression. In addition, contact with the targets in the olfactory bulb is not controlling presynaptic protein gene expression, suggesting that olfactory sensory neurons follow an intrinsic program of development.
File Format	HTM / HTML
ISSN	00219967
e-ISSN	10969861
DOI	10.1002/cne.22094
Journal	Journal of Comparative Neurology
Issue Number	3
Volume Number	516
Language	English
Publisher	Wiley
Publisher Date	2009-09-20
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Neurology Presynaptic Terminals Metabolism Sensory Receptor Cells Physiology Synapses Animals Animals, Newborn Immunohistochemistry In Situ Hybridization Mice Olfactory Bulb Injuries Olfactory Mucosa Rna, Messenger Synaptic Vesicles Vesicular Glutamate Transport Protein 2 Research Support, N.i.h., Extramural
Content Type	Text
Resource Type	Article
Subject	Neuroscience

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