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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Banerjee, Pathikrit Bhattacharyya, Soumya Sundar Bhattacharjee, Nandini Pathak, Surajit Boujedaini, Naoual Belon, Philippe Khuda-Bukhsh, Anisur Rahman |
| Description | Country affiliation: India Author Affiliation: Banerjee P ( Department of Zoology, University of Kalyani, Kalyani-741235, West Bengal, India.) |
| Abstract | Repeated injections of arsenic trioxide induced oxidative stress and hepatotoxicity in mice as revealed from elevated levels of glutamate oxaloacetate transaminases, glutamate pyruvate transaminases, acid and alkaline phosphatases, lipid peroxidation along with reduction of superoxide dismutase, catalase, reduced glutathione content, glutathione reductase and succinate dehydrogenase activities. The present investigation was undertaken to test whether simultaneous feeding of vitamin C can combat hepatotoxicity in arsenic intoxicated mice. Hepatoprotective potential of vitamin C was indicated by its ability to restore GSH, SOD, CAT, AcP, AlkP and GRD levels towards near normal. Electron microscopic studies further supported the biochemical findings confirming the hepatoprotective potential of ascorbic acid. Besides, cytogenetical endpoints (chromosome aberrations, micronuclei, mitotic index and sperm head anomaly) were also analyzed. Administration of vitamin C alone did not show any sign of toxicity of its own. Based on the present findings, ascorbic acid appears to have protective effects against arsenic toxicity and oxidative stress. |
| File Format | HTM / HTML |
| ISSN | 01476513 |
| Issue Number | 2 |
| Volume Number | 72 |
| e-ISSN | 10902414 |
| Journal | Ecotoxicology and Environmental Safety |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2009-02-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Environmental Sciences Antioxidants Pharmacology Arsenic Poisoning Arsenic Toxicity Ascorbic Acid Enzyme Activation Drug Effects Liver Oxidative Stress Animals Drug Therapy Prevention & Control Biological Markers Analysis Physiology Metabolism Mice Micronucleus Tests Microscopy, Electron Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pollution Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health |
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