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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Gillardin, Virginie Silvestre, Frédéric Divoy, Céline Thomé, Jean-Pierre Kestemont, Patrick |
| Description | Country affiliation: Belgium Author Affiliation: Gillardin V ( Unité de Recherche en Biologie des Organismes (URBO), Facultés Universitaires Notre-Dame de la Paix, Rue de Bruxelles 61, B-5000 Namur, Belgium. virginie.gillardin@fundp.ac.be) |
| Abstract | Over the last decades, amphibians decline has been reported worldwide. Exposure to polychlorinated biphenyls (PCBs) is one of the possible causes in addition to climate changes, UV-radiation or habitat destruction. In the present study, we tested the hypothesis that PCBs could induce oxidative stress in young tadpoles. Developing Xenopus laevis were exposed from 2- to 5-d postfertilization (pf) to 0.1 or 1 mg/l of Aroclor 1254. Lipid peroxidation and antioxidant systems (SOD, CAT, GST, GPx, GR activities and t-GSH level) were investigated in whole organisms. Exposure to both concentrations did not impact on the survival and development whereas the average body weight decreased. Exposure to 1 mg/l of Aroclor 1254 induced a significant (p<0.05) increase of GST activity when compared to controls 0 and DMSO. The other antioxidant enzymes and LPO evaluation remained unchanged. Our results demonstrate that exposure of X. laevis tadpoles to environmental concentrations of Aroclor 1254 interfere with normal growth. They also highlight that very young X. laevis tadpoles express antioxidant systems. |
| File Format | HTM / HTML |
| ISSN | 01476513 |
| Issue Number | 2 |
| Volume Number | 72 |
| e-ISSN | 10902414 |
| Journal | Ecotoxicology and Environmental Safety |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2009-02-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Environmental Sciences Antioxidants Metabolism Antithyroid Agents Toxicity Larva Drug Effects Lipid Peroxidation Oxidative Stress Xenopus Laevis Animals Body Weight Glutathione Transferase Growth & Development Physiology Male Superoxide Dismutase Time Factors Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pollution Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health |
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