NDLI: Co-administration of α-Lipoic Acid and Vitamin C Protects Liver and Brain Oxidative Stress in Mice Exposed to Arsenic Contaminated Water

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Co-administration of α-Lipoic Acid and Vitamin C Protects Liver and Brain Oxidative Stress in Mice Exposed to Arsenic Contaminated Water

Content Provider	Springer Nature Link
Author	Kaur, Harshneet Mishra, Deepshikha Bhatnagar, Pradeep Kaushik, Pallavi Flora, Swaran J. S.
Copyright Year	2009
Abstract	Arsenic is one of the most hazardous substances in the environment known to cause toxicity in multiple organs via generation of oxidative stress. The molecular basis for arsenic toxicity involves direct or indirect damage to protein, lipid and DNA. Several studies have focused on possible toxic effects on membrane components and have identified a correlation between these effects of arsenic-induced oxidative damage. This study was aimed to evaluate arsenic-induced oxidative stress in the liver and brain following chronic exposure in mouse and also the protective efficacy of co-administrating with two naturally occurring antioxidants (α-lipoic acid and vitamin C) either individually or in combination. Thirty male mice were exposed to sodium arsenite (50 ppm) alone, as well as to α-lipoic acid (10 mg/kg) and vitamin C either alone or in combination. We observed a significant increase in lipid peroxidation, intracellular calcium, reactive oxygen species (ROS) and caspase activity, while there was a significant decrease in antioxidant enzymes and ATPase activity on arsenite exposure in mice. These alterations were marginally restored by co-administration of vitamin C and α-lipoid acid individually, while significant recovery was observed in the animals supplemented with both the antioxidants together with arsenite in mice. The results indicate that arsenite-induced oxidative stress can be significantly protected by co-administration of α-lipoic acid and vitamin C individually, but the best effects could be observed with combined administration of two antioxidants during arsenite exposure in animals.
Starting Page	135
Ending Page	144
Page Count	10
File Format	PDF
ISSN	18761658
Journal	Exposure and Health
Volume Number	1
Issue Number	3-4
e-ISSN	18761666
Language	English
Publisher	Springer Netherlands
Publisher Date	2009-07-17
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Arsenic toxicity α-Lipoid acid Vitamin C Oxidative stress Antioxidants Co-administration Mouse Environmental Health Pollution Waste Water Technology Water Pollution Control Water Management Aquatic Pollution
Content Type	Text
Resource Type	Article
Subject	Pollution Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health Water Science and Technology

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