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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Zhang, Jian Yu, Xiao-Hua Yan, Yi-Guo Wang, Cheng Wang, Wen-Jun |
| Description | Country affiliation: China Author Affiliation: Zhang J ( Department of Spine Surgery, The First Affiliated Hospital, University of South China, Hengyang, Hunan 421001, China.); Yu XH ( Life Science Research Center, University of South China, Hengyang, Hunan 421001, China.); Yan YG ( Department of Spine Surgery, The First Affiliated Hospital, University of South China, Hengyang, Hunan 421001, China.); Wang C ( Department of Spine Surgery, The First Affiliated Hospital, University of South China, Hengyang, Hunan 421001, China.); Wang WJ ( Department of Spine Surgery, The First Affiliated Hospital, University of South China, Hengyang, Hunan 421001, China. Electronic address: wwwwjj167@qq.com.) |
| Abstract | Osteosarcoma (OS) is the most common nonhematologic bone malignancy in children and adolescents. Despite the advances of adjuvant chemotherapy and significant improvement of survival, the prognosis remains generally poor. As such, the search for more effective anti-OS agents is urgent. The phosphatidylinositol 3-kinase (PI3K)/Akt pathway is thought to be one of the most important oncogenic pathways in human cancer. An increasing body of evidence has shown that this pathway is frequently hyperactivated in OS and contributes to disease initiation and development, including tumorigenesis, proliferation, invasion, cell cycle progression, inhibition of apoptosis, angiogenesis, metastasis and chemoresistance. Inhibition of this pathway through small molecule compounds represents an attractive potential therapeutic approach for OS. The aim of this review is to summarize the roles of the PI3K/Akt pathway in the development and progression of OS, and to highlight the therapeutic potential of targeting this signaling pathway. Knowledge obtained from the application of these compounds will help in further understanding the pathogenesis of OS and designing subsequent treatment strategies. |
| File Format | HTM / HTML |
| ISSN | 00098981 |
| Volume Number | 444 |
| e-ISSN | 18733492 |
| Journal | Clinica Chimica Acta |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-04-15 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Clinical Chemistry Discipline Laboratory Medicine Osteosarcoma Metabolism Phosphatidylinositol 3-kinase Proto-oncogene Proteins C-akt Signal Transduction Humans Drug Therapy Pathology Antagonists & Inhibitors Drug Effects Journal Article Research Support, Non-u.s. Gov't Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biochemistry (medical) Clinical Biochemistry Biochemistry |
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