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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Martínez-Mancera, Flavio Dolores García-López, Patricia Hernández-López, José Luis |
| Description | Country affiliation: Mexico Author Affiliation: Martínez-Mancera FD ( Centro de Investigación y Desarrollo Tecnológico en Electroquímica, S.C., Parque Tecnológico Querétaro S/N, P.O. Box 064, Pedro Escobedo, Querétaro C.P. 76703, Mexico.); García-López P ( Instituto Nacional de Cancerología, Av. San Fernando No. 22, Col. Sección XVI, Del. Tlalpan, México, D.F., C.P. 14080, Mexico.); Hernández-López JL ( Centro de Investigación y Desarrollo Tecnológico en Electroquímica, S.C., Parque Tecnológico Querétaro S/N, P.O. Box 064, Pedro Escobedo, Querétaro C.P. 76703, Mexico. Electronic address: jhernandez@cideteq.mx.) |
| Abstract | BACKGROUND: The ELISA format for measuring carcinoembryonic antigen (CEA) serves as a reference standard against which other assays are compared. Because the World Health Organization (WHO) increasingly recommends the use of serum CEA as a diagnostic tool for cancer, it is relevant to explore the reliability of the new decentralized CEA point-of-care-testing (POCT) technologies that are available to physicians and patients, in compliance with mandates of the clinical laboratories' regulatory agencies. METHODS: Electrochemical immunoassay (ECIA) based on trace lead (Pb) analysis by anodic stripping techniques using sandwich-type immunocomplex conjugates: (MB)Ab/AgCEA/Ab(PbS), and a commercial ELISA test system with optical transmission. RESULTS: The ECIA provides better analytical performance than does the ELISA. The within assay precision coefficient of variance (%CVw) of the ECIA is lower than the value recommended by the Hong Kong Association of Medical Laboratories (HKAML), and the recoveries of CEA at 1.0, 5.0, 10.0, 25.0 and 50.0 ng/ml are in the range of 99-110% for control serum samples. The ECIA showed a minimal positive bias of 0.0267 ± 0.3270 ng/ml (P=0.9389). CONCLUSIONS: The proposed CEA screening technology can be practically employed for decentralized clinical analysis of CEA in human serum. Therefore, it can be viewed as a control method for personalized therapy. |
| File Format | HTM / HTML |
| ISSN | 00098981 |
| Volume Number | 444 |
| e-ISSN | 18733492 |
| Journal | Clinica Chimica Acta |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-04-15 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Clinical Chemistry Discipline Laboratory Medicine Tumor Markers, Biological Blood Carcinoembryonic Antigen Electrochemical Techniques Enzyme-linked Immunosorbent Assay Biostatistics Early Detection Of Cancer Instrumentation Humans Particle Size Surface Properties Journal Article Research Support, Non-u.s. Gov't Validation Studies |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biochemistry (medical) Clinical Biochemistry Biochemistry |
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