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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Marques, T. Patente, T. A. Monteiro, M. B. Cavaleiro, A. M. Queiroz, M. S. Nery, M. de Azevedo, M. J. Canani, L. H. Parisi, M. C. Moura-Neto, A. Passarelli, M. Giannella-Neto, D. Machado, U. F. Corrêa-Giannella, M. L. |
| Spatial Coverage | Brazil |
| Description | Country affiliation: Brazil Author Affiliation: Marques T ( Laboratório de Endocrinologia Celular e Molecular (LIM-25), Faculdade de Medicina da Universidade de São Paulo, Av. Dr. Arnaldo, 455 #4305, 01246-903 São Paulo-SP, Brazil.); Patente TA ( Laboratório de Endocrinologia Celular e Molecular (LIM-25), Faculdade de Medicina da Universidade de São Paulo, Av. Dr. Arnaldo, 455 #4305, 01246-903 São Paulo-SP, Brazil.); Monteiro MB ( Laboratório de Endocrinologia Celular e Molecular (LIM-25), Faculdade de Medicina da Universidade de São Paulo, Av. Dr. Arnaldo, 455 #4305, 01246-903 São Paulo-SP, Brazil.); Cavaleiro AM ( Laboratório de Endocrinologia Celular e Molecular (LIM-25), Faculdade de Medicina da Universidade de São Paulo, Av. Dr. Arnaldo, 455 #4305, 01246-903 São Paulo-SP, Brazil.); Queiroz MS ( Divisão de Endocrinologia, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, R. Dr. Eneas de Carvalho Aguiar, 647, 05403-000 São Paulo-SP, Brazil.); Nery M ( Divisão de Endocrinologia, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, R. Dr. Eneas de Carvalho Aguiar, 647, 05403-000 São Paulo-SP, Brazil.); de Azevedo MJ ( Divisão de Endocrinologia, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, R. Ramiro Barcelos, 2350, 90035-903 Porto Alegre-RS, Brazil.); Canani LH ( Divisão de Endocrinologia, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, R. Ramiro Barcelos, 2350, 90035-903 Porto Alegre-RS, Brazil.); Parisi MC ( Divisão de Endocrinologia, Departamento de Clínica Médica, Faculdade de Medicina da Universidade Estadual de Campinas (UNICAMP), Rua Tessália Vieira de Camargo, 126, 13084-971 Campinas-SP, Brazil.); Moura-Neto A ( Divisão de Endocrinologia, Departamento de Clínica Médica, Faculdade de Medicina da Universidade Estadual de Campinas (UNICAMP), Rua Tessália Vieira de Camargo, 126, 13084-971 Campinas-SP, Brazil.); Passarelli M ( Laboratório de Lípides (LIM-10), Faculdade de Medicina da Universidade de São Paulo, Av. Dr. Arnaldo, 455 # 3305, 01246-903 São Paulo-SP, Brazil.); Giannella-Neto D ( Programa de Pós-Graduação em Medicina, Universidade Nove de Julho-UNINOVE, São Paulo-SP, Brazil.); Machado UF ( Departmento de Fisiologia e Biofísica, Instituto de Ciências Biomédicas da Universidade de São Paulo, Av. Prof. Lineu Prestes 1524, 05508-900 São Paulo-SP, Brazil.); Corrêa-Giannella ML ( Laboratório de Endocrinologia Celular e Molecular (LIM-25), Faculdade de Medicina da Universidade de São Paulo, Av. Dr. Arnaldo, 455 #4305, 01246-903 São Paulo-SP, Brazil) |
| Abstract | Mesangial cells subject to high extracellular glucose concentrations, as occur in hyperglycaemic states, are unable to down regulate glucose influx, resulting in intracellular activation of deleterious biochemical pathways. A high expression of GLUT1 participates in the development of diabetic glomerulopathy. Variants in the gene encoding GLUT1 (SLC2A1) have been associated to this diabetic complication. The aim of this study was to test whether polymorphisms in SLC2A1 confer susceptibility to diabetic nephropathy (DN) in Brazilian type 1 diabetes patients. Four polymorphisms (rs3820589, rs1385129, rs841847 and rs841848) were genotyped in a Brazilian cohort comprised of 452 patients. A prospective analysis was performed in 155 patients. Mean duration of follow-up was 5.6 ± 2.4 years and the incidence of renal events was 18.0%. The rs3820589 presented an inverse association with the prevalence of incipient DN (OR: 0.36, 95% CI: 0.16 - 0.80, p=0.01) and with progression to renal events (HR: 0.20; 95% CI: 0.03 - 0.70; p=0.009). AGGT and AGAC haplotypes were associated with the prevalence of incipient DN and the AGAC haplotype was also associated with the prevalence of established/advanced DN. In conclusion, rs3820589 in the SLC2A1 gene modulates the risk to DN in Brazilian patients with inadequate type 1 diabetes control. |
| File Format | HTM / HTML |
| ISSN | 00098981 |
| Volume Number | 444 |
| e-ISSN | 18733492 |
| Journal | Clinica Chimica Acta |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-04-15 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Clinical Chemistry Discipline Laboratory Medicine Diabetes Mellitus, Type 1 Genetics Diabetic Neuropathies Glucose Transporter Type 1 Polymorphism, Single Nucleotide Adult Brazil Cross-sectional Studies Female Genotype Humans Male Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biochemistry (medical) Clinical Biochemistry Biochemistry |
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